特发性便秘患者乙状结肠粘膜VIP、NOS阳性神经的变化  

The Abnormalities of Vasoactive Intestinal Polypeptide and Nitric Oxide Synthase Positive Nerves in Colon in Idiopathic Chronic Constipation(ICC) Patients

作　　者：易宏辉[1] 李富军[2] 邹益友[2] 

机构地区：[1]长沙市卫生学校,湖南长沙410100 [2]中南大学湘雅医院消化内科,湖南长沙410008

出　　处：《现代生物医学进展》2008年第4期679-680,682,共3页Progress in Modern Biomedicine

基　　金：湖南省教委科研基金(编号2001-B64)

摘　　要：目的:研究特发性便秘患者乙状结肠粘膜内VIP、NOS阳性神经的变化情况。方法:利用免疫组化技术研究了8例特发性便秘患者乙状结肠粘膜内VIP、NOS阳性神经的变化情况并与5例健康人相比较。结果:特发性便秘患者乙状结肠粘膜内NOS阳性神经较正常人明显增多(P<0.01)。结论:特发性便秘的发病可能与结肠内NO产生增多有关。Objective： To investigate changes of VIP, NOS positive nerves in colon in patients with idiopathic chronic constipation. Methods： We studied 8 ICC patients and 5 controls by immunohistochemistry using anti-VIP and anti-nitric oxide synthase antibodies to evaluate the density of VIP and nitric oxide producing nerves in colonic mucosa. Results： The patients of idiopathic chronic constipation （ICC） showed high density of NO S positive nerve fibers in the colon. Conclusion： The pathogenesis of idiopathic chronic constipation （ICC） may partly be related to the changes of NOS positive nerves in the colon.

关 键 词：便秘 一氧化氮合酶 血管活性肠肽 结肠测压 免疫组化 

分 类 号：R574.62[医药卫生—消化系统]