吡柔比星和多柔比星在乳腺癌新辅助化疗中的短期临床疗效比较  

Comparison between short-term efficacy of neoadjuvant chemotherapy with THP and ADM in patients with breast cancer

作　　者：徐鹏[1] 李妙玉 温红[1] 

机构地区：[1]青岛市肿瘤医院外一科,山东青岛266042

出　　处：《中国肿瘤临床与康复》2008年第2期165-167,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的对比观察采用吡柔比星(THP)和多柔比星(ADM)为主的新辅助化疗方案治疗乳腺癌的疗效和毒副作用。方法126例乳腺癌患者于手术前采用CTF方案治疗75例,采用CAF方案治疗51例,分别进行2个周期化疗后进行评估。结果全组总有效率(CR+PR)是74.6%,其中CTF组为77.3%,CAF组70.6%,两组之间差异无显著性。不良反应:肝功能异常、白细胞减少、血小板减少、恶心呕吐等两组间比较差异无显著性;吡柔比星组脱发及心肌损害发生率低于多柔比星组,差异有显著性。结论吡柔比星、多柔比星对乳腺癌新辅助化疗的疗效无差异,THP组脱发、心肌损害轻于ADM组。Objective To observe the efficacy and adverse effects of neoadjuvant chemotherapy with THP or ADM in patients with breast cancer. Methods Of the 126 patients before operation, 75 adopted neoadjuvant chemotherapy with CTF regimen for two cycles and 51 adopted neoadjuvant chemotherapy with CAF regimen for two cycles. Then all patients were evaluated. Results The overall response rate （ CR ＋ PR） was 74. 6%, the response rate of the CTF regimen was 77. 3% and that of the other was 70. 6%. The efficacy of CTF regimen was not superior to that of CAF regimen. To the major adverse effects, there was no distinct difference in hepatic dysfunction, neutropenia,thrombocytopenia and nansea/vomiting between the two regimens, but alopecia and cardiomyopathy were milder in THP regimen as compared with ADM regimen. Conclusion The efficacy of the two kinds of neoadjuvant chemotherapy was approximative ,while alopecia and cardiomyopathy were a little milder in THP regimen as compared with ADM regimen.

关 键 词：吡柔比星 多柔比星 乳腺肿瘤/化学疗法 

分 类 号：R737.9[医药卫生—肿瘤] R730.53[医药卫生—临床医学]