巴曲酶注射液治疗发病72h后急性脑梗死的研究  

Study of the therapy with Batroxobin on acute cerebral infarction after 72h of onset

作　　者：庞英[1] 孙玉衡[1] 韩仰同[1] 郭笑磊[1] 

机构地区：[1]北京积水潭医院神经内科,北京100035

出　　处：《中风与神经疾病杂志》2008年第1期73-75,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的比较巴曲酶注射液对发病72h^5d(试验组)与发病6~72h(对照组)急性脑梗死的治疗作用及其安全性。方法对两组60例患者应用巴曲酶注射液静脉滴注隔日1次,共3次。首次为10BU,另两次各为5BU。用药前、治疗后2h、12h±20min、24h±20min、3d、7d、14d、1个月及3个月时进行NIHSS评分,在1个月和3个月时进行简易智能量表(mini-mental state examination,MMSE)、Barthel指数(Barthel Index,BI)、改良的Rankin量表(Modified Rankin Scales,MRS)和安全性评价。结果试验组神经功能恢复在用药后2h NIHSS评分即开始改善,对照组在用药后12h开始改善;两组在其他各时间点均较用药前显著改善。试验组在用药后3个月的BI、MMSE评价比用药后1个月时有显著进步。两组均无不良事件发生。结论巴曲酶注射液对发病72h^5d急性脑梗死的治疗安全、有效。Objective Comparing the therapy and safety of on Batroxobin acute cerebral infarction between experimental group （72h -5d after onset） and control group （6 -72h after onset）. Methods Sixty cases of two groups were intravenous administrated every other day with Batroxobin for 3 times. The first doses was lOBU,the other two was 5BU. We recorded the NIHSS before therapy, after 2h, 12h ± 20min ,24h±20min ,3d,7d, 14d, 1 month and 3 month. Mini-mental state examination（ MMSE）, Barthel Index （BI）, Modified Rankin Scales （MRS） and safety evaluation ware collected at 1 and 3 month. Results NIHSS of experimental group was improved at 2h after therapy,that of control group was improved at 12h. Two groups were significantly improved at other points, Evaluation of BI and MMSE was more remarkably improved at 3 month than 1 month in experimental group, Two groups had no adverse effect, Conclusion Batroxobin is effective and sate to acute cerebral infarction after 72h onset

关 键 词：巴曲酶注射液 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]