依达拉奉治疗脊髓损伤的临床研究  

Clinical study of edaravone in the treatment of spinal cord injury

作　　者：孙洪涛[1] 涂悦[1] 李建伟[1] 张赛[1] 

机构地区：[1]武警医学院附属医院脑系科中心,天津300162

出　　处：《中风与神经疾病杂志》2008年第1期76-78,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的观察依达拉奉对脊髓损伤的疗效。方法67例脊髓损伤患者分为治疗组和对照组，对照组采用常规治疗，治疗组在常规治疗基础上加用依达拉奉注射液静滴，观察临床疗效。结果治疗组33例有32例取得Frankell-3级的改善，平均改善2．0级，1例A级无变化。对照组34例有31例Frankell-3级改善，平均改善1.4级，恢复到E级10例，远少于治疗组18例。总体而言，在感觉恢复、日常生活活动能力、膀胱功能上，治疗组自身治疗前后及治疗组与对照组治疗后比较无明显改善。结论依达拉奉注射液治疗脊髓损伤有一定效果，对脊髓损伤细胞具有保护作用，能促进脊髓损伤神经功能的恢复。Objective To observation of edaravone on the efficacy of spinal cord injury. Methods 67 cases of spinal cord injury patients was included into treatment group and the control group. The control group accepted conventional treatment and the treatment group on the basis of conventional therapy plus edaravone intravenous injection. Results In the treatment group ,32 cases of 33 cases gained Frankell - 3 improvements, improveing 2.0 average, while one Class A Unchanged. 31 cases in the control group gained Frankell - 3 improved,improving 1.4 average, 10 cases return to E, far less than 18 cases of the treatment group. Conclusion Edaravone injection in the treatment of spinal cord injury has good effect on spinal cord injury in a protective role. Spinal cord injury can significantly promote neurological recovery.

关 键 词：依达拉奉 脊髓损伤 自由基 

分 类 号：R744[医药卫生—神经病学与精神病学]