口腔鳞癌免疫化疗近期疗效的临床和病理学观察  

Obsercation of clinical and pathological responses in short-term following immunochemotherapy for oral squamous cell carinoma

作　　者：胡勤刚[1] 邱蔚六[2] 沈言备[1] 金友仁[1] 陈君勤[1] 

机构地区：[1]江苏省南京市口腔医院,210008 [2]上海第二医科大学口腔医学院,200011

出　　处：《上海口腔医学》1997年第3期144-147,166,共5页Shanghai Journal of Stomatology

摘　　要：24例T3、T4期口腔鳞癌患者随机分组后接受术前诱导治疗，其中13例行免疫化疗（沙塔林15KE＋CDDP70mg／m2＋VCR1·4mg/m2＋PYM80mg，S-PVP），11例行单纯化疗（CDDP90mg／m2＋VCR1．4mg／m2＋PYM80mg，PVP）作对照。通过对诱导治疗前后临床肿瘤大小的测量和手术切除标本的组织病理学检查．评价免疫化疗和单纯化疗的临床及病理学疗效。结果为S－PVP组的临床和病理学疗效分别为92．3％和84．6％8而PVP组则分别为727％和45．5％。S－PVP组与PVP组间在病理学疗效上有显著性差异（P＜0．05），表明术前免疫化疗的近期疗效优于单纯化疗。与临床疗效评价相比，病理学疗效评价似更为客观、准确，可作为临床疗效评价的重要补充手段。24 Patients with oral SCC in Stage T3 or T4 were randomly divided into twogroups, and treated with two inductive therapies, 13 cases of whom received an immu-mochemotherapy regimen (Sapylin 15 KE+CDDP 70mg/m2 +VCR 1. 4mg/m2 + PYM 80mg,S-PVP) and 11 cases, a chemotherapy regimen (CDDP 90mg/m2 + VCR 1. 4mg/m2 + PYM 80mg, PVP ) as control. The clinical response and pathological effect after im-munochemotherapy or chemotherapy were evaluated through the clinical measurement of tu-mor size and histological examiation of the specimen. The results showed that the rate of clini-cal and pathological responses in S-PVP group were 92. 3% and 84.6%, respectively; and inPVP group, 72. 7% and 45. 5%. There was a significant difference between two groups inpatholgical effect (P<0.05),which indicated that the S-PVP regimen in short-term was bet-ter than of inductive chemotherapy. It may be relatively objective and accurate in comparisonwith clinical investigation which could act as an important supplement to the evaluation of clin-ical response.

关 键 词：口腔鳞癌 口腔肿瘤 免疫疗法 化学疗法 

分 类 号：R739.8[医药卫生—肿瘤]