HO-CO系统与肝硬化门脉高压血液动力学改变的研究进展  

Research progress in the relationship between HO-CO pathway and haemodynamic variation of cirrhotic portal hypertension

作　　者：段志军[1] 刘洁[1] 赵钢[1] 杨冬[1] 李蕾蕾[1] 

机构地区：[1]大连医科大学附属第一医院消化科,辽宁省大连市116011

出　　处：《世界华人消化杂志》2008年第8期874-878,共5页World Chinese Journal of Digestology

基　　金：辽宁省科技攻关资助项目;No.225003~~

摘　　要：肝硬化门脉高压患者多存在高动力循环状态,有报道血红素氧合酶(hemeoxygenase,HO)与内源性一氧化碳(carbon monoxide,CO)作为HO-CO系统在血管调节中发挥重要的生物学效应,与肝硬化门静脉高压(portal hypertension,PH)的持续存在、肝微循环变化以及高动力循环状态有着密切的关系.本文将从肝硬化PH的血液动力学改变、HO-CO系统的生物学活性和HO-CO系统与PH的血液动力学改变等三部分的研究进展作一综述.Hyperkinetic circulation may present in patients with cirrhotic portal hypertension. Some papers about hemeoxygenase/endogenous carbon monoxide as HO-CO pathway, which significantly affects the regulation of blood vessel and correlates closely with the persistence of portal hypertension, variation of hepatic microcirculation and hyperkinetic circulatory state in cirrhotic portal hypertension, were published. This article gives a brief overview on the above respects in three parts, which were haemodynamic variation of cirrhotic portal hypertension, biologic activity of HO-CO pathway and their correlations.

关 键 词：HO-CO系统 肝硬化 门静脉高压 

分 类 号：R575.2[医药卫生—消化系统]