环境雌激素致雄性生殖系统发育异常途径的研究进展  

Pathways of environmental estrogens caused male reproductive system maldevelopment

作　　者：张升敏[1] 蒋学武[1] 

机构地区：[1]汕头大学第二附属医院小儿外科,广东汕头515031

出　　处：《生殖医学杂志》2008年第2期151-155,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金资助(30571935)

摘　　要：大量动物实验表明环境雌激素(EEs)具有生殖和(或)发育毒性,其致雄性生殖系统发育畸形的机制复杂,尤其作用途径目前仍很不明了。本文从EEs干扰睾丸发育、影响睾丸激素产生、代谢并进而致雄性生殖系统发育畸形的可能途径介绍近年来国内外取得的进展。It has been shown that numerous natural and synthetic chemicals with estrogenic activities have reproductive or developmental toxicity in humans or animals by epidemiological investigations and animal experiments. The mechanisms of toxicity that could result in male reproductive system maldevelopment, however, are very complicated, especially in the exact pathways. This article introduced the current progress on the potential pathways of environmental estrogens （exoestrogens, xenoestrogens） interfered with the testicular development, testicle hormone production and their metabolism.

关 键 词：环境雌激素 雄性生殖系统 发育异常 睾酮 INSL3 SERTOLI细胞 LEYDIG细胞 

分 类 号：R331[医药卫生—人体生理学]