前列腺癌组织中肿瘤血管生成的研究  

Tumor Angiogenesis in Prostatic Carcinoma

作　　者：李月明[1] 李玉魁[1] 张桂芬[1] 孙智才[1] 魏国红[1] 揣文香 郭敏茹 张秘 

机构地区：[1]中国人民解放军第二五四医院泌尿外科,天津市300142

出　　处：《中国肿瘤临床》1997年第10期728-731,共4页Chinese Journal of Clinical Oncology

摘　　要：为探讨前列腺癌（PCa）细胞转移的机制，应用免疫组织化学SP法在36例良性前列腺增生（BPH）及34例PCa组织中对第Ⅷ因子相关抗原进行表达，计数微血管（MV），发现PCa组织中MV数显著高于BPH组（P＜0.01），浸润性PCa组MV数明显高于局限性PCa组（P＜0．05），伴淋巴结转移者MV数显著高于无淋巴结转移者（P＜0．05），未分化PCa组MV数显著高于高分化组及低分化组（P＜0．05），提示肿瘤血管生成与PCa分期、分级密切相关，癌细胞的浸润及转移有赖于肿瘤血管的生成。Microvessels were identified by immunostaining endothelial cellsfor factor VIII related antigen. We have counted microvessels within the tissue of36 cases of benign prostatic hyperplasia (BPH) and 34 cases of prostatic carcinoma(PCa). The results revealed that 1) the mean microvessel count (MVC) in PCawas significantly higher than that in BPH (P<0.01); 2) the MVC in invasive PCawas significantly higher than that in localized PCa (P<0.05); 3) the MVC of primary PCa with metastasis was higher than without tnetastasis (P<0. 05), and 4)MVC corresponded well with the histological grading of tumor. It is postulated thattumor angiogenesis assessed by MVC corresponds well with the stage and gradingof PCa and that the infiltration and rnetastasis requires tumor angiogenesis.

关 键 词：前列腺肿瘤 血管生成 微血管计数 

分 类 号：R737.25[医药卫生—肿瘤]