中晚期前列腺癌的综合治疗(附45例报告)  

Combination Therapy for Advanced Prostatic Cancer Analysis f 45 Cases

作　　者：徐培玉[1] 李慧灵[1] 陈路川[1] 

机构地区：[1]福建省肿瘤医院,福州市350014

出　　处：《中国肿瘤临床》1997年第9期678-681,共4页Chinese Journal of Clinical Oncology

摘　　要：1986年12月到1995年6月共收治中晚期前列腺癌45例，均经病理证实。按Jewett分期：C期17例、D1期6例、D2期22例。治疗采用在去势治疗基础上，以放射治疗、内分泌治疗以及对D2期骨转移的部分病人同时用骨增综合治疗。结果显示：1、3年生存率分别为97．8％、57.6％、C期5年生存率达60％。放射治疗对于C期及D1期是一种有效的治疗，8MV－X和18MV－X射线照射，DT60～75Gy／6～8周。D2期大部分以缓退瘤治疗，每日口服750mg，连续2～3月，症状改善和客观效应均较理想。有骨转移者采用转移灶止病性放疗及配合缓退瘤、骨腾治疗，症状改善及转移灶稳定或消失，副作用小。Forty-five patients with moderately or far advanced prostatic cancer histologically proven were treated with combination therapy in the period of 1986～1995. All the patients staged according to Jewett classification were treated primarily with surgical castration in combination with radiotherapy or endocrinotherapy, whereas clodronate was added in patients who had bone metastasis. The results showed that 1-, 3-year survival rates were 97. 8%, 57. 6% respectively, and that the 5-year survival of stage C patients was 60%. The authors believe that radiotherapy using 8mv or 18mv at doses of 60～75Gy/6～8 weeks would be sufficient for stage C and D1 patients. Flutamide yields good response for stageD2,and,palliative radiotherapy in combination with flutamide and clodronate givesgood result for metastatic stage D2.

关 键 词：前列腺肿瘤 放射疗法 缓退瘤 骨膦 中晚期 

分 类 号：R737.25[医药卫生—肿瘤] R730.55[医药卫生—临床医学]