p-p38和uPA在胃癌组织中的表达及意义  

The Expressions of p-p38 and Urokinase-Type Plasminogen Activator and Their Significance in Gastric Carcinoma

作　　者：张科[1] 毛福荣[2] 郭琦[2] 

机构地区：[1]郑州市第五人民医院ICU,河南郑州450003 [2]郑州大学医学院,河南郑州450052

出　　处：《肿瘤基础与临床》2008年第2期116-118,共3页journal of basic and clinical oncology

摘　　要：目的研究磷酸化p38(p-p38)和尿激酶型纤溶酶原激活剂(uPA)在胃癌组织中的表达及与临床病理特征的关系。方法采用免疫组织化学方法检测35例胃癌组织标本中p-p38和uPA的表达并分析其相关性及与临床病理特征进行比较。结果胃癌组织中p-p38及uPA的阳性表达率分别为62.9%和60.0%。p-p38和uPA表达均为阳性17例,表达均为阴性9例,两者表达一致的符合率为74.3%(26/35),其表达呈密切相关(P<0.05);两者与胃癌的浸润程度、淋巴结转移密切相关(P<0.05),而与患者年龄、性别无显著相关性(P>0.05)。结论p-p38及uPA过表达在胃癌的发展及浸润转移中具有重要的作用,p-p38和uPA的表达可辅助用于胃癌的预后评估。Objective To study the expressions of phosphorylated p38 （p-p38）and urokinase-type plasminogen activator（uPA） and their relationship with the clinicopathological features in gastric carcinoma. Methods The expressions of p-p38 and uPA were determined by immunohisto-chemical method in 35 cases with gastric carcinoma . The relationship between the expressions of p-p38 and uPA and the clinicopathological features was analyzed. Results The positive expression rates of p-p38 and uPA in gastric carcinoma were 62.9% and 60.0%. Both p-p38 and uPA expressions were positive in 17 cases and negative in 9 cases. There was a close relationship between the p-p38 and uPA expressions. The expressions of p-p38 and uPA were correlated with development, infiltration and lymph node metastasis, but no relationship was found between their expressions and the patient＇ s age and sex. Conclusions The overexpressions of p-p38 and uPA play an important role in the development, invasion, and metastasis of stomach cancer.

关 键 词：磷酸化P38 尿激酶型纤溶酶原激活剂 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]