微管引流灌注顺铂治疗中等或大量恶性心包积液80例临床观察  

Clinical Observation of Intrapericardial Minicatheter Drainage and Intrapericardial Injection with Cisplatin in the Treatment of Malignant Pericardial Effusion

作　　者：顾洪兵[1] 姚卫东[1] 宋诸臣[1] 陆俊国[1] 陈冬梅[1] 谭清和[1] 吉志固[2] 李明[3] 

机构地区：[1]南通市肿瘤医院化疗科,江苏南通226361 [2]南通市肿瘤医院病理科,江苏南通226361 [3]南通市肿瘤医院检验科,江苏南通226361

出　　处：《肿瘤基础与临床》2008年第2期145-146,共2页journal of basic and clinical oncology

摘　　要：目的评价微管心包腔闭式引流灌注顺铂治疗中等或大量恶性心包积液的疗效。方法将80例中等量或大量恶性心包积液行微管心包腔闭式引流术；心包积液引净后注入顺铂（DDP）80mg。结果CR30例（37．5％），PR40例（50．0％），有效率87．5％（70／80），中位生存期205d；引流量（500～2800mL）明显多于既往常规心包穿刺抽液（100～500mL）。结论微管引流灌注顺铂治疗中大量恶性心包积液疗效佳，且安全、方便、易行，可作为治疗中大量恶性心包积液的首选方法。Objective To evaluate the clinical efficacy of intrapericardial minicatheter drainage and intrapericardial injection with cisplatin in the treatment of malignant pericardial effusion. Methods 80 patients with malignant pericardial effusion were treated by intrapericardial minicatheter drainage and intrapericardial injection with cisplatin. Results The effective rate and median survival were 87.5% （70/80） and 205 days. Conclusions This study showed that intrapericardial minicatheter drainage and intraperlcardial injection with cisplatin may he the best way to control malignant perieardial effusion.

关 键 词：心包积液 穿刺术 引流 顺铂 

分 类 号：R730.6[医药卫生—肿瘤] R730.53[医药卫生—临床医学]