环丙沙星-聚羟基丁酸酯电纺纤维毡的制备、性质及抑菌活性研究  

Preparation,characteristics and bacteria inhibition of the electrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin

作　　者：李梅[1] 韩高义[1] 张立伟[1] 

机构地区：[1]山西大学化学生物学与分子工程教育部重点试验室分子科学研究所

出　　处：《化学研究与应用》2008年第4期475-478,共4页Chemical Research and Application

基　　金：国家自然科学基金(20604014)资助项目;科技部科技支撑计划(2006BAI06A20-10)资助项目

摘　　要：Eelectrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin are prepared by electrospinning,and the surface morphology of the fibrous mats is investigated by scanning electron microscope.The efficiency of encapsulation,drug release behavior in vitro,and anti-bacteria activity of the fibrous mats are studied.The results show that the entrapment efficiency of electrospun scaffolds nearly reached 100%;the drug release duration is about 25 days,and the drug release of about 57% can be observed in initial 24h.The conclusions are that the electrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin have good function of controlled release,and it can inhibit the growth of S.aureus very well.Eelectrospun polyhydroxylbntyrate fibrous mats containing ciprofloxacin are prepared by electrospinning, and the surface morphology of the fibrous mats is investigated by scanning electron microscope. The efficiency of encapsulation, drug release behavior in vitro, and anti-bacteria activity of the fibrous mats are studied. The results show that the entrapment efficiency of electrospun scaffolds nearly reached 100% ; the drug release duration is about 25 days , and the drug release of about 57% can be observed in initial 24h. The conclusions are that the electrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin have good function of controlled release, and it can inhibit the growth of S. aureus very well.

关 键 词：电纺纤维毡聚羟基丁酸醋 环丙沙星 缓释 抑菌活性 

分 类 号：O633.14[理学—高分子化学]