子宫肉瘤的术前彩色多普勒超声诊断与血管生成的定量研究  

Study on Sarcoma of Uterus for Its Color Doppler Ultrasonographic Diagnosis and Angiogenesis

作　　者：陈昭日[1] 戴淼[1] 陈相英[1] 

机构地区：[1]潍坊医学院附属医院妇科,山东潍坊261031

出　　处：《潍坊医学院学报》2008年第1期50-52,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨子宫肉瘤的彩色多普勒超声血流特点及血管生成。方法术后病理证实的9例子宫肉瘤患者为研究组,63例子宫肌瘤患者为对照组。两组患者均于术前1周内行经阴道彩色多普勒超声检查。检查时记录其子宫及病变部位的形态结构特点、血流信号,并测量血流多普勒阻力指数(RI)。术后9例肉瘤组织和20例肌瘤组织应用免疫组化SABC法进行血管内皮染色并行微血管密度检测(MVD)。结果①肉瘤组的肿瘤周围和/或中央区均能探及较丰富的血流信号,而肌瘤组能探及的血流信号以周边分布为主。肉瘤组子宫动脉血流及肿瘤血流RI值均明显低于肌瘤组(P<0.05);②肉瘤组肿瘤的MVD明显高于肌瘤组(P<0.01)。结论术前检测子宫肉瘤的彩色多普勒血流特征、判断其血管化程度,有助于提高诊断准确性;子宫肉瘤的微血管生成明显活跃,为肉瘤的抗血管生成治疗提供了理论依据。Objective To study the sarcoma of uterus in color Doppler flow characteristics and angiogenesis. Methods Nine uterine sarcomas and 63 myomas were enrolled in. They were examined by transvaginal color Doppler uhrasonography before operation. Morphologic changes and color flow image in the uterine lesions were noted. Resistance index values（RI） of uterine arteries and blood flow in the lesions was also measured. Results （1）Vascular signals could be seen centrally and/or outerly in all the sarcomas while most outerly in myomas and,scarcely centrally. There was significant difference between sarcomas and myomas in regard to the blood flow resestance index values（RI） of uterine arteries and tumor arteries（ P 〈0.05）. （2）There was also significant difference between sarcomas and myomas in microvessel density（MVD） （P 〈 0.01）. Conclusion color Doppler ultrasonography before operation. It is useful sis in sarcomas is of great value in the treatment. Vaseularization in sarcomas can be analyzed by transvaginal to improve lhe diagnosis of sareonmas. Exploring the angiogenesis in sarcomas is of great value in the treatment.

关 键 词：子宫肿瘤 彩色多普勒超声 血管生成 

分 类 号：R737.33[医药卫生—肿瘤]