孤独症儿童多巴胺转运体脑内显像研究  

Study of Dopamine Transporter Imaging on the Brain of Children with Autism

作　　者：孙晓勉[1,2] 岳静[1] 郑崇勋[1] 

机构地区：[1]西安交通大学生命科学与技术学院生物医学工程研究所,西安交通大学生物医学信息工程教育部重点实验室,西安720021 [2]广东省深圳市福田区妇幼保健院儿保科,深圳518026

出　　处：《生物医学工程学杂志》2008年第2期327-330,共4页Journal of Biomedical Engineering

摘　　要：通过单光子发射计算机断层扫描(SPECT)技术,对孤独症儿童组和对照组进行脑部SPECT扫描,观察孤独症儿童脑内多巴胺转运体(DAT)的分布,结果显示观察组和对照组纹状体中DAT分布有明显差别(P=0.017)。使用SPECT技术对孤独症儿童脑内DAT分布进行监测,可达到早期发现,早期干预,并为寻求有效的药物治疗提供理论依据。This study was conducted to evaluate the applicability of ^99mTc-2β-[N, N＇-bis（2-mercaptoethyl） ethylenediamino]methyl,3β-（4-chlomphenyl）tmpane（TRODAT-1 ）dopamine transporter（DAT） SPECT imaging in children with autism, and thus to provide an academic basis for the etiology, mechanism and clinical therapy of autism. Ten autistic children and ten healthy controls were examined with ^99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of 99^99mTc-TRODAT-1 was calculated with region of interest analysis acmrding to the ratios between striaturn and cerebellum[（STR-BKG）/BKG]. There was no statistically significant difference in semiquantitative dopamlne transporter between the bilateral striata of autistic children（ P = 0. 562）, and between those of normal controls（ p = 0. 573） ; Dopamine transporter in the brain of patients with autism increased significantly as compared with that in the brain of normal controls （ P = 0.017 ）. Dopaminergic nervous system is dysfunctioning in the brain of children with autism, and DAT ^99mTc-TRODAT-1 SPECT imaging on the brain will help the imaging diagnosis of childhood autism.

关 键 词：多巴胺转运体 儿童孤独症 ^99MTC-TRODAT-1 单光子发射计算机断层扫描 

分 类 号：R749.94[医药卫生—神经病学与精神病学]