壳聚糖纳米给药系统及其在眼科学领域的应用  

Application of chitosan-based nanoparticles drug delivery system in ophthalmology

作　　者：王丽曌[1] 王雨生[1] 

机构地区：[1]第四军医大学西京医院眼科全军眼科研究所,中国陕西省西安市710032

出　　处：《国际眼科杂志》2008年第4期784-787,共4页International Eye Science

基　　金：全军医药卫生科研项目(No.06M261);中国陕西省自然科学基金(No.2004C246)~~

摘　　要：基于壳聚糖的纳米给药系统已成为药物治疗研究的热点之一。壳聚糖纳米给药系统除了具有一般纳米给药系统的特点,如靶向输送、可生物降解和缓释外,还具有其他载体不具备的如抑菌、止血、抗组织纤维化、辅助免疫、抗肿瘤和促进伤口愈合等特性。目前的研究结果已展示出在眼科疾病治疗中的应用前景。Considerable research attentions have been attracted by chitosan and chitosan-based nanoparticles drug delivery system.As a biomedical material,it has some unique biological activities,including antibacteria,hemostasis,immuno-enhancing effects,antitumor activity and healing promotion,besides characteristics of general drug-loaded nanoparticlies such as targeting,biodegradability and sustained release.The present findings on chitosan have shown application prospects in treating ocular diseases.

关 键 词：壳聚糖 纳米微粒 给药系统 眼科学 

分 类 号：R77[医药卫生—眼科]