结肠癌中P27^kipl与Ki67的表达及其临床意义  

Expression of P27^kipl and Ki67 in colonic cancer and their clinical significance

作　　者：王贵红[1] 陈雷[2] 王富顺[2] 郑兰东[1] 皇甫深强[1] 

机构地区：[1]河南大学第一附属医院普通外科,开封475001 [2]北京大学人民医院普通外科

出　　处：《中原医刊》2008年第7期17-19,共3页Central Plains Medical Journal

摘　　要：目的 探讨P27^kipl和Ki67的表达与结肠癌的发生、发展的关系。方法采用免疫组织化学方法检测64例结肠癌组织和癌旁正常组织中P27^kipl和Ki67的表达。结果P27^kipl和Ki67在结肠癌组织中的阳性表达率分别为23．44％和46．88％，它们在癌旁正常组织中的阳性表达率分别为87．50％和3．13％。P27^kipl和Ki67在结肠癌中的表达与年龄、性别无关（P〉0．05），与不同分化程度、Dukes分级和淋巴结是否转移有关（P〈0．05）。且P27kipl与Ki67的表达呈负相关（P〈0．05）。结论P27^kipl的表达下调和Ki67的表达上调在结肠癌的发生、发展和转移过程中起着重要的作用。Objective To explore the expressions ofP27^kipl and Ki67 were correlated with genesis and progression of human colonic cancer. Methods Expressions of P27^kipl and Ki67 at protein level were determined by using immunohistochemistry technique in 64 eases of tissue and side tissue of colonic cancer. Results The positive expression rates of P27^kipl and Ki67 in colonic cancer issue were 23.44% and 46. 88% ,and side issue were 87.50% and 3.13%. The expressions of P27^kipl and Ki67 in colonic cancer were not related to age or sex （ P 〉0.05）,and related to differentiation grade,Dukes stage and lymph node metastasis（ P 〈0.05）. A sig- nificant negative correlation was observed between the expression of P27^kipl and Ki67（ P 〈0. 05）. Conclusion The downregulation of P27^kipl and upregulation of Ki67 play an important role in the genesis, progression and metastasis of colonic cancer.

关 键 词：结肠癌 基因表达 P27^KIPL KI67 

分 类 号：R735.9[医药卫生—肿瘤] R735.35[医药卫生—临床医学]