微量热法研究β-环糊精与6-苄氧基嘌呤和6-苄氨基嘌呤的主-客体相互作用  

Study on Host-Guest Interaction of β-Cyclodextrin with 6-Benzyl-oxypurine and 6-Benzylaminopurine Utilizing Microcalorimetry

作　　者：赵强[1] 张骞[1] 刘杰[1] 邢生凯[1] 孙得志[1] 

机构地区：[1]聊城大学化学化工学院,聊城252059

出　　处：《化学学报》2008年第7期827-830,共4页Acta Chimica Sinica

基　　金：山东省自然科学基金(No.2004ZX15)资助项目

摘　　要：在298.15K下,用微量热法测定了重要植物生长调节物质6-苄氧基嘌呤(6-BOP)和6-苄氨基嘌呤(6-BAP)与β-环糊精(β-CD)在pH=8.9的水溶液中包合作用的热效应,进而用非线性拟合法计算出了主-客体包合物的化学计量比、平衡常数、标准焓变和标准熵变等热力学参数.结合主-客体相互作用的紫外光谱信息,从6-苄氧基嘌呤和6-苄氨基嘌呤的分子结构出发讨论了主-客体分子相互作用的强弱以及热力学数据的差异.结果表明,β-环糊精对6-苄氧基嘌呤和6-苄氨基嘌呤具有明显的分子识别功能.Thermal effect of inclusion process of β-cyclodextrin （β-CD） with 6-benzyloxypurine （6-BOP） and 6-benzylaminopurine （6-BAP） in aqueous solution at pH=8.9 has been determined with microcalorimetry at the temperature 298.15 K. Standard enthalpy changes, stoichiometry, and equilibrium constants of the inclusion complexation have been derived based on the direct calorimetric data utilizing non-linear simulation. The thermodynamic parameters were discussed in the light of different structures of the guest molecules combining with UV spectral message of the host-guest interaction. The result indicates that β-CD possesses obvious function of molecular recognition to 6-benzyloxypurine and 6-benzylaminopurine.

关 键 词：6-苄氧基嘌呤 6-苄氨基嘌呤 Β-环糊精 分子识别 微量热法 

分 类 号：O626[理学—有机化学]