无溶剂条件下合成2-[3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮  

Synthesis of 2-{3-Oxo-1,3-di[(un)substituted phenyl]propyl}-1,2,3,4- tetrahydronaphthalen-1-ones under Solvent-Free Condition

作　　者：荣良策[1,2] 韩红霞[1] 蒋虹[3] 李小跃[1] 姚昌盛[1] 屠树江[1,2] 

机构地区：[1]徐州师范大学化学化工学院 [2]江苏省药用植物生物技术重点实验室徐州221116 [3]江苏省药用植物生物技术重点实验室

出　　处：《有机化学》2008年第4期746-749,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20772103);徐州师范大学自然科学基金(No.06XLA09)资助项目.

摘　　要：以3,4-二氢-1-萘酮和查尔酮为原料,在K2CO3-NaOH存在下,无溶剂室温研磨反应,方便地得到2-[3-氧代-1,3-二(未)取代苯基丙基]-1,2,3,4-四氢萘-1-酮.该方法具有反应条件温和、操作简单和产率较高等优点,并通过IR,1HNMR,元素分析确定了产物的结构,3b晶体结构通过X衍射测定.The synthesis of 2- { 3-oxo- 1,3-di[（un）subsfituted phenyl]propyl}- 1,2,3,4-tetrahydronaphthalen- 1-ones from chalcones and 1-tetralone was carried out in excellent yields in the presence of K2CO3-NaOH under a solvent-free condition at room temperature using a grinding method. This protocol has the advantages of mild reaction conditions, simple procedure and high yields. The structures of the products were characterized on the basis of IR, ^1H NMR spectroscopic data, elemental analysis, and that of 3b was additionally confirmed by X-ray diffraction analysis.

关 键 词：1-四氢萘酮 查尔酮 无溶剂 合成 

分 类 号：O625.4[理学—有机化学]