E-cadherin和C-erbB2在非小细胞肺癌中的表达及其临床病理意义  

The Expression of E-cadherin and C-erbB2 in NSCLC and theirs Significances

作　　者：刘汉勇[1] 王晓玫[1] 单军[2] 成志强[1] 蔡进中[1] 彭全洲[1] 胡锦涛[1] 

机构地区：[1]暨南大学第二临床学院,深圳市人民医院病理科 [2]暨南大学第二临床学院,深圳市人民医院放射科

出　　处：《中国误诊学杂志》2008年第13期3025-3028,共4页Chinese Journal of Misdiagnostics

基　　金：深圳市科技计划项目资助(编号:200404027)

摘　　要：目的:研究非小细胞肺癌(NSCLC)中E-cadherin和C-erbB2蛋白的表达状况,分析其临床病理意义。方法:用免疫组化方法对82例非小细胞肺癌标本和20例正常肺组织进行免疫组化检测。结果:正常肺组织E-cadherin表达;4例C-erbB2+表达,无C-erbB2过表达。NSCLC中E-cadherin表达率为(49%),低分化组NSCLC E-cadherin表达率为30%,明显低于中高分化组表达率60%(P=0.010);中晚期(+)NSCLC表达率为31%,明显低于早期(+)NSCLC表达率62%(P=0.007);淋巴结转移组NSCLC表达率为39%,低于无淋巴结转移组表达率65%(0.026),均有统计学意义。肺腺癌C-erbB2表达率为45%,高于鳞癌过表达率17%(P=0.017);中晚期NSCLC(+)过表达率为51%,高于早期(+)过表达率21%(P=0.004);淋巴转移组过表达率为41%,高于无淋巴转移组过表达率23%(P=0.028)。E-cadherin的低表达和C-erbB2过表达无相关性。结论:E-cadherin低表达和C-erbB2过表达在肺癌的发生、发展和淋巴结转移中可能扮演重要的角色,联合检测对判断NSCLC生物学行为有病理临床意义。Objective：To investigate the the expression of E-cadherin and C-erbB2 protein in no-small cell lung cancer （NSCLC） and analyze the relationship between their expression and pathological significance, explore the relationship between E-cadherin and C-erbB2 at protein levels. Methods ：To test the protein expression of E-cadherin and C- erbB2 in 20 normal lung tissues and 82 NSCLC tissues by immunochemistry. Results ：E-cadherin was normally expressed in all normal lung tissues ,and C-erbB2＋expression was detected in 4 case of 20 normal lung tissue but no overexpression was detected, in all NSCLC cases,the E-cadherin normal expression rate was 49% and its normal expression rate of lower differentiated group is 30% and statistically lower than that in high differentiated group（60%）; the normal expression rate of lymph transfer group was statistically lower than the group which had no lymph node transferred （P= 0. 010）;the normal expression rate （31% ）of E-cadherin in TNM Ⅲ＋Ⅳ group is significantly lower than that （62 %） in TNM Ⅰ-Ⅱ group （P=0. 003）. The overexpression rate of C-erbB2 in lung adenocarcinoma was 45.5% while overexpression rate was 19.9% in the squamous carcinoma,these differences have statistics meanings （P= 0. 039） . The overexpression rate in Lymph transfer group （43.2%） was remarkably higher than the group （18. 5% ）which has not been transferred （P=0. 033）. C erbB2 overexpression correlated with TNM staging, the overexpression of C-erbB2 in TNM Ⅲ＋Ⅳ group is significantly higher than that in TNM Ⅰ ＋ Ⅱ group （P=0. 003）. There was no relationship between E-cadherin reduced expression and C-erbb2 overexpression in NSCLC. Conclusion：E-cadherin reduced expression and C- erbB2 overexpression may play an important role in the development and lymph node metastasis of NSCLC, and the combination test of E-cadherin and cerbb2 has pathological significance for judging the biological behavior of NSCLC.

关 键 词：钙粘着糖蛋白类/代谢 衔接蛋白质类 信号转导/代谢 癌 非小细胞肺/代谢/病理学 肺肿瘤/代谢/病理学 淋巴转移 人类 

分 类 号：R734.2[医药卫生—肿瘤]