加速适形放疗非小细胞肺癌的疗效观察  

Observation of Effect of Accelerated-fraction Three-dimensional Conformal Radiation on Non-small Cell Lung Cancer

作　　者：刘阿秋[1] 贾明[1] 李智军[1] 

机构地区：[1]内蒙古自治区医院肿瘤放疗科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2008年第3期291-292,共2页Inner Mongolia Medical Journal

摘　　要：目的：观察Ⅱ、Ⅲ期非小细胞肺癌加速分割三维适形放疗的近期疗效、1年生存率及放射反应。方法：58例未能手术治疗的Ⅱ、Ⅲ期非小细胞肺癌,采用6MVX线加速分割三维适形放疗,2.3-3.0Gy/f、1f/d、5f/w,总DT：57.5-61Gy/25f。对近期疗效、1年生存率、放疗反应进行总结和分析。结果：本组治疗总有效率为75.8%,1年生存率为85.4%。急性放射性气管炎、肺炎发生率为17.4%（10/58）,急性放射性食管炎发生率为22.4%（13/58）,肺纤维化发生率为1.7%（1/58）。结论：加速分割三维适形放疗能够有效提高未能手术Ⅱ、Ⅲ期非小细胞肺癌的局控率,急性放疗反应能耐受,近期疗效满意。Objective： To observe the effects , one - year survival rate and complication of accelerated - fraction three - dimension conformal radiotherapy on non - small cell lung cancer patients with Ⅱ and Ⅲ stage. Methods：Fiftyeight patients with stage Ⅱ and Ⅲ NSCLC were treated by accelerated fraction three- dimensional conformal radiotherapy of 6 MV X radiation., 2.3 Gy/f, 1 f/d, 5 f/w , the total dose 57.5--61 Gy . The clinical shortterm effects, I year survival rate and the adverse effects were evaluated. Result： The overall response rate （ CR ＋ PR） was 75.8 %, 1 year survival rate was 85.4 %. The acute radiation pneumonitis , tracheitis and esophagealis were respectively 17.4 % and 22.4%. The radiation pulmonary fibrosis occurred in 1.7 % （1/58）. Conclusion： The accelerated - fraction three - dimension conformal radiotherapy can effectively improve the local control rate of inoperable NSCLC patients. It has relatively low rate of complication and has overall satisfactory short- term effects.

关 键 词：加速分割三维适形放疗 非小细胞肺癌 放射反应 

分 类 号：R730.55[医药卫生—肿瘤] R734.2[医药卫生—临床医学]