前列腺癌多b值扩散加权成像研究  

Prostate Carcinoma:Multi-b Values Diffusion Weighted Imaging

作　　者：任静[1] 宦怡[1] 常英娟[1] 赵海涛[1] 葛雅丽[1] 张劲松[1] 刘燕丽[1] 徐俊卿[1] 

机构地区：[1]第四军医大学西京医院放射科,陕西西安710032

出　　处：《实用放射学杂志》2008年第4期502-504,576,共4页Journal of Practical Radiology

摘　　要：目的研究不同b值前列腺癌的扩散加权成像(DWI)表现,比较表观扩散系数(ADC)之间的差异,探讨最佳b值的选取。方法对20例经病理证实的前列腺癌(Pca)患者行DWI扫描,b值分别取0s/mm2,250s/mm2,500s/mm2和750s/mm2,观察前列腺癌不同b值的DWI表现,计算前列腺癌与周围组织之间的对比度,测量癌灶的ADC值并作统计学分析。结果20例前列腺癌在b=0s/mm2时呈低信号影,b=250s/mm2时5例呈低信号影,6例呈等信号影,9例表现为稍高信号影,b值取500s/mm2和750s/mm2时呈高信号影,b值分别取250s/mm2,500s/mm2和750s/mm2时,Pca与周围组织的对比度依次为(6.355±4.261)%,(11.426±5.689)%和(19.528±5.712)%,在不同b值DWI测得前列腺癌与周围组织对比度之间差异有统计学意义(F=31.857,P<0.05);Pca的ADC值依次为(1.463±0.143)×10-3mm2/s,(1.199±0.121)×10-3mm2/s和(0.929±0.120)×10-3mm2/s,不同b值测得前列腺癌ADC值之间差异有统计学意义(F=86.618,P<0.05)。结论750s/mm2是较佳b值,Pca呈高信号影,获得的DWI图像对比度最好,可测得相对准确的ADC值,有助于其定性诊断。Objective To investigate the diffusion weighted imaging （DWI） and the apparent diffusion coefficient （ADC） values of prostate carcinoma （Pea） in different b factors, and to determine the optimal b factor of Pca. Methods 20 patients with proven Pca were scanned with DWI respectively, b factors were set as 0, 250, 500 and 750 s/mm^2. Their DWI and ADC map appearances were analyzed. The ADC values of the Pea foci among different b factors were measured. The contrast between Pea and normal tissues around in different b factors were calculated. Results When b factor was 0 s/mm^2 , all the 20 Pca showed low signal intensity. When b factor was 250 s/mm^2 , 5 eases showed low signal intensity, 6 cases showed iso -signal intensity, and 9 cases showed slight high signal intensity. As b factors were 500 and 750 s/mm2, all the 20 Pca showed high signal intensity. The mean ADCs for the Pca foci were （1. 463 ± 0. 143）× 10^-3 mm^2/s, ｜ 1. 199± 0. 121 ）× 10^-3 mm^2/s, and （0. 929 ±0. 120 ） ×10^-3 mm^2/s when b factors were 250, 500 and 750 s/mm^2 respectively （ one -way ANOVE , F = 86. 618, P 〈 0.05 ）. The mean contrasts between Pea and surrounding normal tissues were （ 6. 355 ±4. 261 ） % , （ 11. 426± 5. 689）% , and （ 19.528 ±5.712） % when b factors were 250, 500 and 750 s/mm2 respectively （ one -way ANOVE,F =31. 857,P 〈0.05）. Conclusion 750 s/mm^2 is the optimal b factor for DWI of Pea. Pea showed high signal intensity on DWI which can be helpful in the qualitative diagnosis.

关 键 词：前列腺癌 扩散加权成像 表观扩散系数 对比度 

分 类 号：R737.25[医药卫生—肿瘤] R445.2[医药卫生—临床医学]