血红蛋白水平对多发性骨髓瘤预后的影响  

Prognostic significance of hemoglobin level in multiple myeloma

作　　者：周胜玉[1] 蔡晓燕[1] 

机构地区：[1]安徽省立医院安徽医科大学省立附属医院血液科,安徽合肥230001

出　　处：《临床和实验医学杂志》2008年第4期39-41,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的通过比较血红蛋白(Hb)水平的变化及其与其他相关预后因素之间的关系,探讨Hb对多发性骨髓瘤(MM)预后的影响。方法将52例初诊多发性骨髓瘤患者按贫血的不同程度分组与相关因素比较并进行治疗前后的自身比较、分析。结果MM患者均有不同程度贫血,Hb水平与骨髓浆细胞总数、乳酸脱氢酶(LDH)、β2-微球蛋白(β2-MG)、C-反应蛋白(CRP)等因素均呈不同程度负相关,与白蛋白呈正相关,与疾病分期关系密切;不同程度贫血病人治疗后Hb水平明显提高,中度以下贫血直接影响生存期。结论血红蛋白可以作为多发性骨髓瘤判断预后的一个独立因素。Objective To investigate the prognostic significance of hemoglobin （Hb） level in patients with multiple myeloma （MM） through the comparison of relationship among variation of hemoglobin level and other relative prognostic factors. Methods Fifty - two patients with multiple myeloma were grouped according to the degree of severity of their anemia, and it was compared with relative factors before and after treatment. Resuits All patients with MM were suffered from different degree of anemia. There was negative correlation among Hb level and total number of clonal plasma cells in bone marrow, levels of lactate dehydrogenase , β2 - microglobulin and C - reactive protein, and it had positive correlation with serum albumin, and it also had a close correlation with disease staging. The Hb level was apparently elevated after treatment. , and the level below moderate degree of anemia was directly influenced on life span of patients. Conclusion Hemoglobin level can be adopted as an independent factor for prediction of the prognosis of patients with multiple myeloma.

关 键 词：多发性骨髓瘤 血红蛋白 独立因素 

分 类 号：R733.3[医药卫生—肿瘤] R714.14[医药卫生—临床医学]