胆管癌组织中Seprase蛋白表达的临床病理意义  

Clinicopathologic Significance of Seprase Protein Expression in Cholangiocarcinoma

作　　者：苗建军[1] 尚培中[1] 朱习琴[1] 贾国洪[1] 李晓武[1] 

机构地区：[1]解放军251医院普通外科,河北张家口075000

出　　处：《华北国防医药》2008年第2期10-11,F0003,共3页Medical Journal of Beijing Military Region

摘　　要：目的:探讨胆管癌组织中Seprase蛋白表达的临床病理意义。方法:采用免疫组化法检测45例胆管癌和10例正常胆管组织中Seprase蛋白表达水平,并结合其与临床病理特征的关系进行分析。结果:Seprase在胆管癌和正常胆管组织中的表达阳性率分别为62.2%(28/45)和0(0/10),差异有统计学意义(P<0.05)。Seprase蛋白表达与胆管癌的分化程度、TNM分期和转移有关(P<0.05)。结论:Seprase蛋白表达在胆管癌的发生和发展过程中起一定作用,检测其表达可以预测胆管癌的预后。Objective ： To investigate clinicopathologic significance of Seprase protein expression in cholangiocarcinoma. Methods ： Immunohistochemical method was used to detect the expression of Seprase protein in 45 cases of cholangiocarcinoma and 10 normal choledochus. The relationship between the expression of Seprase protein and the clinicopathologic characteristics was analyzed. Results：The positive rate of Seprase protein in cancer tissue was 62.2% （28/45） and 0 （0/10） , higher than that in normal tissue and with statistical significance （ P 〈 0.05 ）. There was a significant correlation between Seprase protein expression and clinical stage and lymph node metastasis（ P 〈 0.05 ）. Conclusion：Seprase protein is involved in the development of cholangiocarcinoma and may be a potential predictive marker of prognosis.

关 键 词：胆管肿瘤 SEPRASE 肿瘤转移 预后 

分 类 号：R735.8[医药卫生—肿瘤]