初治晚期肺癌132例患者营养状况调查  

Investigation on the nutrition status of 132 advanced lung cancer patients in primary treatment

作　　者：李榕[1] 马美丽[1] 宋懿懿[1] 裴俊[1] 钟润波[1] 钱嘉琳[1] 颜波[1] 张雪燕[1] 沈洁[1] 韩宝惠[1] 

机构地区：[1]上海交通大学附属上海市胸科医院肺内科,上海200030

出　　处：《肿瘤》2008年第4期353-356,共4页Tumor

摘　　要：目的：调查住院初治Ⅲ～Ⅳ期肺癌患者的营养状况。方法：采用患者总体主观评分法（patient generated-subjective global assessment，PG-SGA）问卷评价132例住院初治Ⅲ～Ⅳ期肺癌患者和38例肺部良性疾病患者的营养状况，同时检测体质指数（body mass index，BMI）、全血总淋巴细胞计数、血红蛋白、血清白蛋白、运铁蛋白、前白蛋白、乳酸脱氢酶、空腹血糖、胆固醇、甘油三酯、尿素氮和肌酐。结果：PG-SGA分级A级19例（14％），B级53例（39％），C级60例（47％）。PG．SGA评分0～1分3例（2．3％），2～8分72例（54．5％），≥9分57例（43．2％）。肺癌患者PG-SGA分级C级比例明显高于肺部良性疾病患者。在PG-SGA分级的A、B、C3级之间Ⅲ～Ⅳ期住院肺癌患者BMI和血清白蛋白均有明显差异，在B、C2级之间年龄和血红蛋白有明显差异。骨髓抑制情况与化疗方案中联合用药数量有关。结论：初治Ⅲ～Ⅳ期住院肺癌患者中蛋白质-能量营养不良的发生率较高。PG-SGA与以BMI、血清白蛋白、血红蛋白为指标的传统营养评价之间有良好的一致性。Objective ：To investigate the nutrition status of lung cancer patients in stage Ⅲ and Ⅳ who were admitted in hospital and receive primary treatment. Methods： One hundred and thirty two lung cancer patients and 38 benign lung disease patients were prospectively investigated using patient generated-subjective global assessment （PG-SGA）. Body mass index （ BMI）, total lymphocyte count, hemoglobin, serum albumin, iron transferring protein, pre-albumin, LDH, fasting glucose, cholesterol, triglycerides, blood urea nitrogen and creatinine levels were detected. Results：There were 19 （ 14% ） lung cancer patients in grade A, 51 （39%） in grade B and 60（47% ） in grade C based on PG-SGA score. Seventy two patients （54.5%） had PG-SGA score at 2 to 8 and 57 （42.2%） lung cancer patients had PG-SGA score ≥9, and only 3（2.3% ） lung cancer patients had PG-SGA score between 0 to 1. The ratio of lung cancer patients in grade C was significantly higher than benign lung disease patients. In lung cancer patients at stage Ⅲ and Ⅳ, BMI and serum albumin were significantly different between A, B and C 3 grades ; age of patients and hemoglobin level were significantly different between B and C 2 grades. The chemotherapy-induced bone marrow suppression correlated with the number of combined drugs. Conclusion：The admitted lung cancer patients at stage Ⅲ and Ⅳ had high protein-energy malnutrition rates. There was good consistency between PG-SGA score and traditional nutritional assessment indicated by BMI, serum albumin, and hemoglobin.

关 键 词：肺肿瘤 营养不良 患者总体主观评分法 

分 类 号：R734.2[医药卫生—肿瘤]