食管鳞癌患者血清VEGF水平检测及临床意义分析  

Determination of Serum VEGF and its Clinical Significance in Patients with Esophageal Squamous Cell Carcinoma

作　　者：尹惠卿[1] 孙莉[1] 段昱[1] 毛红丽[1] 

机构地区：[1]河南省郑州大学第一附属医院检验科,450052

出　　处：《实用全科医学》2008年第5期527-528,共2页Applied Journal Of General Practice

摘　　要：目的探讨食管鳞癌患者血清血管内皮生长因子(VEGF)表达的临床意义。方法采用ELISA法测定69例食管鳞癌患者及38名健康人VEGF水平。结果食管鳞癌患者组血清VEGF水平[(428.0±39.5)ng/L],明显高于正常对照组[(212.0±23.5)ng/L](P<0.01);血清VEGF表达水平与临床分期有关,与年龄、性别等因素无关。结论食管鳞癌患者血清VEGF的表达水平可作为食管鳞癌预后判断的一个较好指标。Objective To study the clinical significance of serum vascular endothelial growth factor（VEGF） in patients with esophageal squamous cell carcinoma（ESCC）. Methods The level of serum VEGF in 69 patients with ESCC and 38 healthy controis was measured by ELISA. Results The levels of serum VEGF in patients with ESCC （428 ± 39.5 ） ng/L was significantly higher than that of control（212.0 ± 23.5 ） ng/L） （P 〈 0.01 ）. The expression of serum VEGF level was associated with clinical stage of ESCC, but not with the sex and age of the patients. Conclusions The level of serum VEGF assay may be used to estimate prognosis of ESCC.

关 键 词：血管内皮生长因子 食管鳞癌 预后判断 

分 类 号：R735.1[医药卫生—肿瘤]