碱性功能化离子液体催化Mannich反应研究  

Mannich Reaction Catalyzed by Basic Functionalized Ionic Liquid

作　　者：巩凯[1] 方东[1] 施群荣[1] 刘祖亮[1] 

机构地区：[1]南京理工大学化工学院,江苏南京210094

出　　处：《含能材料》2008年第2期121-124,共4页Chinese Journal of Energetic Materials

基　　金：江苏省教育厅科研资助项目(No07KJD530238)

摘　　要：研究了碱性功能化离子液体氢氧化1-丁基-3-甲基咪唑([bmim]OH)催化环己酮、芳香醛、芳香胺的三组分Mannich反应。原料比例为n(环己酮):n(芳香醛):n(芳香胺):n([bmim]OH)=1:1:1:0.1,以乙醇为溶剂,室温条件下反应10h,生成相应的β-氨基酮,产率达75%～91%。探讨了溶剂种类和醛、胺的结构对Mannich反应的影响。离子液体可以重复使用5次,其催化活性并未明显降低。Three-component Mannich reaction of cyclohexanone, aromatic aldehydes and aromatic amines catalyzed by a basic functionalized ionic liquid, 1-butyl-3-methylimidazolium hydroxide （ [ bmim ] OH）, was investigated. Under the optimum reaction conditions as n（cyclohexanone） ： n（ aromatic aldehydes） ： n（ aromatic amines） ： n（ [ bmim] OH） = 1 ： 1 ： 1 ： 0.1, and at room temperature for 10 h with CH3CH20H as a solvent, the yields of β-amino ketones was obtained with 75% -91%. The factors influencing the Mannich reaction were discussed including solvents, the structure of aldehydes and amines. The ionic liquid, which is environment friendly, was recycled at least 5 times without significant loss of activity.

关 键 词：有机化学 功能化离子液体 MANNICH反应 催化 β-氨基酮 

分 类 号：O643.32[理学—物理化学]