CD_(105)和VEGF在星形细胞瘤组织中的表达及意义  

Expression and clinical significance of CD105 and VEGF in human astrocytoma

作　　者：李少梅[1] 王树兴[1] 于春玲[1] 姜京超 姜慧峰[1] 

机构地区：[1]烟台市莱阳中心医院,山东莱阳265200

出　　处：《山东医药》2008年第11期30-32,共3页Shandong Medical Journal

基　　金：山东省科学技术厅资助项目(2007-561)

摘　　要：目的探讨CD105和VEGF在星形细胞瘤组织中的表达及临床意义，为星形细胞瘤的临床治疗提供理论依据。方法采用免疫组化法检测正常脑组织、低级别（Ⅰ～Ⅱ级）和高级别（Ⅲ～Ⅳ级）星形细胞瘤组织及瘤旁组织中CD105和VEGF蛋白表达。结果星形细胞瘤组织中CD105标染的微血管密度（CD105-MVD）和VEGF蛋白表达水平明显高于瘤旁组织和正常脑组织（P〈0．01）；Ⅰ～Ⅱ级星形细胞瘤组织中CD105-MVD和VEGF蛋白表达水平均高于Ⅲ～Ⅳ级星形细胞瘤；星形细胞瘤组织中VEGF高表达者CD105-MVD显著高于低表达者和阴性表达者（P〈0．05），低表达者高于阴性表达者（P〈0．05）。结论CD105和VEGF在星形细胞瘤中的表达关系密切，其联合检测可能对判断星形细胞瘤恶性程度有重要价值，以二者为靶点的抗肿瘤措施将为星形细胞瘤的生物治疗带来新的选择。Objective To investigate the expression and clinical significance of CD105 and VEGF in astrocytoma, and supply evidence of clinical treatment. Methods Immunochemical method was used to determine the expression of CD105 and VEGF protein in 56 cases of low-grade astrocytomas and paratumor tissue, and 56 cases of high-grade astrocytomas and paratumor tissue, and 10 cases of normal brain tissues were used as control group. Results Compared to the control group and paratumor tissue, the CD105-MVD and VEGF immunopositive cells were increased significantly in the astrocytomas（ P 〈 0. 01 ）. The expression of CD105-MVD and VEGF were increased significantly in the high-grade astrocytomas versus to the low-grade astrocytomas. There were statistically significant about CD105-MVD among the significantly expressed group, the lower expressed group and negative group of VEGF （P 〈 0. 05）. Conclusions The CD105 and VEGF protein are over-expressed in human astrocytomas to a centain extent, and the positive rate of expression gradually improves with the histological grade becoming more serious, which may be combined utilized to discriminate the malignant degree of astrocytoma. The new therapeutic regimen of astrocytoma based on these will be applied.

关 键 词：星形细胞瘤 血管内皮生长因子 转化生长因子-Β 

分 类 号：R739.9[医药卫生—肿瘤]