大剂量免疫球蛋白治疗Guillain-Barre综合征的疗效观察  

Curative effects observation of Guillain-Barre syndrome treated with large dose of immunoglobulin

作　　者：徐丙超[1] 何明利[1] 徐英达[1] 

机构地区：[1]徐州医学院附属连云港医院神经内科,222002

出　　处：《临床神经病学杂志》2008年第2期153-154,共2页Journal of Clinical Neurology

摘　　要：目的观察大剂量静脉注射免疫球蛋白(IVIG)治疗Guillain-Barre综合征(GBS)的疗效。方法将34例急性GBS患者随机分为IVIG治疗组(IVIG组)和常规治疗组(对照组)(各17例),IVIG组用人免疫球蛋白0.4g/(kg.d)静脉注射,连续5d;其他治疗两组相同。治疗21d后评定临床疗效。结果IVIG组治愈率(52.9%)及总有效率(100%)明显高于对照组(11.8%,76.5%)(均P<0.05),且四肢肌力、呼吸肌瘫痪、感觉障碍、脑神经损害开始改善的时间明显短于对照组(均P<0.001)。结论大剂量IVIG治疗GBS有显著疗效,无明显不良反应。Objective To observe the curative effects of Guillain-Barre Syndrome （GBS） treated with large dose of immunoglobulin. Methods 34 patients with acute GBS were randomly divided into intravenous immunoglobulin （IVIG） group and control group （ 17 cases in each group）. The patients in IVIG group were treated with intravenous injection of human immunoglobulin 0.4 g/（ kg·d） for five days, while the other treatment of two groups was similar. The curative effects was evaluated at 21 days after therapy. Results The cure-rate （52.9%） and total effective rate （ 100% ） in IVIG group were signifcantly higher than those in control group （ 11.8% and 76. 5% ）（ all P 〈 0. 05 ）. The paralysis of limbs muscle and respiratory muscle, the sensory disability and the cerebral nerve lesion in the IVIG group were more rapidly improved than those of the control group （all P 〈 0. 001 ）. Conclusions Treated with large does IVIG in GBS has significantly curative effects, that is free fom obvious side effect.

关 键 词：GUILLAIN-BARRE综合征 免疫球蛋白 

分 类 号：R745.43[医药卫生—神经病学与精神病学]