snthr^(-1Bao)稀毛小鼠皮肤组织的病理变化  

Pathological development in the skin of scant hair mouse,snthr^(-1Bao)

作　　者：吴宝金[1] 茅慧华 殷俊 陈兵 薛整风 李厚达 

机构地区：[1]扬州大学医学院,扬州225002 [2]扬州大学比较医学中心,扬州225002

出　　处：《解剖学杂志》2008年第2期181-184,共4页Chinese Journal of Anatomy

基　　金：国家自然科学基金(30400266)

摘　　要：目的:观察snthr-1Bao稀毛小鼠皮肤组织及其他主要脏器的病理变化。方法:取2月龄snthr-1Bao稀毛小鼠和正常DBA/2J小鼠的主要脏器,两品系4、5、6、7、8周龄小鼠的睾丸、附睾、子宫、卵巢以及胚胎18·5d、初生、1周、2周、1月、2月6个年龄段背部肩胛间皮肤,常规处理后行石蜡切片,光镜观察;取2月龄小鼠背部毛发行扫描电镜观察。结果:snthr-1Bao稀毛小鼠除皮肤外,其他内脏器官均无明显病理变化,扫描电镜见毛发鳞片边缘略粗糙,皮肤病变始发于出生后1~2周,随年龄增长,病变加重。原发病变表现为皮肤棘层肥厚、角化过度及部分毛发结构缺陷、继发病变为部分毛发皮内卷曲、折断、皮肤损伤并引发局部非感染性炎症,继而导致疤痕形成。结论:snthr-1Bao小鼠病理变化主要表现在皮肤组织,1~2周龄间是病变的关键期。Objective： To observe the pathological changes in the skin and other organs of snthr^1Bao mouse. Methods： The organs including the heart, liver, spleen, lung, kidney, brain, lymph node, thymus, intestine and Peyer＇s patch of 2-month-old mice, the testis, epididymis, ovary and uterus at the age of 4, 5, 6, 7, 8 weeks, and the skin tissue between scapulae of mice at the age of embryonic 18.5d, postnatal 1 day, 1 week, 2 weeks, 1 month and 2 months were taken and treated with the routine methods of paraffin section and observed under microscopy. Dorsal hair was hocked for SEM observation. snthr^1Bao mice were the experimental group controlled with its background strain DBA/2J. Results： No pathological changes were found in the checked organs of snthr^1Bao mouse except the skin. The pathological changes in the skin were initiated between 1 and 2 week and exhibited acanthosis, hyper-keratosis and structural disfigurements in some hair as primary affections. The following pathological changes included hair curling, broken, impairment in the skin and local noninfective inflammation which resulted in scarring. Hair scale edge looked a little bit coarse under SEM. Conclusion： For the snthr^1Bao mouse, the skin is the only organ showing dominant pathological changes which start during 1 to 2 weeks.

关 键 词：snthr^-1Bao小鼠 皮肤 病理 

分 类 号：R361.2[医药卫生—病理学]