三七茎叶皂苷水解产物中稀有抗肿瘤成分的化学研究  

Studies on the Chemical Constituents of The Hydrolysate of The Stems and Leaves of Panax notoginseng(Burk.) F.H.Chen

作　　者：胡晗绯[1] 韩凌[1] 赵余庆[2] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]沈阳药科大学,辽宁沈阳110016

出　　处：《中国现代中药》2008年第4期6-8,共3页Modern Chinese Medicine

摘　　要：目的:研究三七茎叶皂苷水解产物的化学成分。方法:采用各种色谱技术进行分离纯化,利用理化常数测定和光谱数据分析进行结构鉴定。结果:从三七茎叶皂苷水解产物中分离得到8个化合物,分别鉴定为达玛烷-20(22)-烯-3β,12β,25-三醇[dammarane-20(22)-en-3β,12β,25-panaxatriol,Ⅰ],20(R)-达玛烷-3β,6α,12β,20,25-五醇[20(R)-dammarane-3β,6α,12β,20,25-pentol,Ⅱ],20(R)-达玛烷-3β,12β,20,25-四醇[20(R)-dammarane-3β,12β,20,25-triol,Ⅲ],20(S)-人参二醇[20(S)-panaxadiol,20(S)-PD,Ⅳ],20(S)-原人参二醇[20(S)-protopanaxadiol,20(S)-PPD,Ⅴ],20(R)-原人参二醇[20(R)-protopanaxadiol,20(R)-PPD,Ⅵ],20(S)-人参三醇[20(S)-panaxatriol,20(S)-PT,Ⅶ],20(S)-25-甲氧基-达玛烷-3β,12β,20-三醇[20(S)-25-me-thoxyl-dammarane-3β,12β,20-triol,Ⅷ]。结论:化合物Ⅱ和Ⅴ为首次从三七茎叶皂苷水解产物中分得。Objective： To study the chemical constituents of the hydrolysis of Panax notoginseng （Burk） F. H. Chen. Methods： Isolated and purified compounds by kinds of chromatography technogies and identified them by their spectral data and physico-chemical properties. Results： Eight compounds were isolated and identified. Their structures were identified as ： damrnarane-20 （ 22 ） en-3β, 12β, 25-panaxatriol （ Ⅰ ）, 20 （R） -dammarane-3β, 6α, 12β, 20, 25-pentol（ Ⅱ ）, 20（R） -dammarane-3β, 12β, 20, 25-triol（Ⅲ）, 20（S）-panaxadiol（Ⅳ）, 20（S）-proto- panaxadiol （ Ⅴ ）, 20 （R） -protopanaxadiol （ Ⅵ ）, 20 （ S ） -panaxatriol （ Ⅶ）, 20 （ S ） -25-methoxyl-dammarane-3β, 12β, 20-triol （Ⅷ）. Conclusion： Compounds Ⅱ , Ⅴ were isolated from the acid hydrolytic products of the stems and leaves of Panax notoginseng（Burk） F. H. Chen for the first time.

关 键 词：三七茎叶 人参皂苷衍生物 水解产物 化学研究 

分 类 号：R285.5[医药卫生—中药学] R991[医药卫生—中医学]