膀胱移行细胞癌PCNA表达及其临床意义和预后价值  

Expression of PCNA and Its Clinical Significance and Prognostic Value in Transitional Cell Bladder Cancer

作　　者：罗宁玲[1] 黄志勇[1] 王益华[1] 周祀侨[1] 

机构地区：[1]南京大学医学院附属鼓楼医院病理科

出　　处：《南京医科大学学报（自然科学版）》1997年第5期472-474,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：应用免疫组化（ＡＢＣ）法检测５１例膀胱移行细胞癌增殖细胞核抗原（ＰＣＮＡ）表达，并探讨其与病理分级、临床分期和预后的关系。结果显示，ＰＣＮＡ表达与分级、分期关系非常显著（Ｐ均＜０．０１）；复发组和死亡组之间ＰＣＮＡ表达明显高于无复发组（Ｐ均＜０．０１）。提示，ＰＣＮＡ的高表达在判断膀胱移行细胞癌病人复发和恶化方面是一项重要的指标。Expression of proliferating cell nuclear antigen (PCNA) was determined by immunohistochemical ABC method in 51 cases of transitional cell bladder cancer (TCC). The relationship among the expression of PCNA, histological grade, clinical stage and prognostic value was explored. The results showed that expression of PCNA was closely related to the determinant in histological grade and clinical stage ( P< 0.01). The expression of PCNA in recurrent and dmortale groups was much higher than that of the nonrecurrencce group ( P <0.01). The results suggest that over expression of PCNA may serve as an important index in predicting malignancy and recurrence of TCC.

关 键 词：膀胱肿瘤 增殖细胞核抗原 免疫组化 预后 

分 类 号：R737.14[医药卫生—肿瘤]