膀胱移行细胞癌HPV的表达与肿瘤细胞空穴症的对比研究  

Cellular vacuolation and human papillomavirus expression in transitional cell carcinoma of bladder

作　　者：段国兰[1] 王志平[1] 徐晨阳[1] 史庭恺[1] 陈一戎[1] 刘国栋[1] 马幼兰[1] 伍莲生[1] 

机构地区：[1]兰州医学院第二附属医院泌尿外科研究所

出　　处：《中华泌尿外科杂志》1997年第9期553-554,共2页Chinese Journal of Urology

摘　　要：为了探究高危型ＨＰＶ与膀胱癌发生发展的关系，证实细胞空穴症乃ＨＰＶ感染的病理组织学表现。采用ＰＣＲ技术检测４８例明显细胞空泡化的膀胱移行细胞癌石蜡标本ＨＰＶＤＮＡ。结果：４０例阳性（８３．３％），其中强阳性８例。结果表明细胞空穴症是人移行细胞、鳞状细胞ＨＰＶ感染的病理形态学特征，膀胱移行细胞癌细胞空穴症与高危型ＨＰＶ密切相关，高危型ＨＰＶ感染是膀胱癌的病因之一。HPV DNA was assayed by polymerase chain reaction technique (PCR) in 48 transitional cell carcinom of bladder with significant cell vacuolation. Strong or medium HPV expression was detected in 83.0% of the carcinoma tissues suggesting a close relationship between cell vacuolation and HPV infection. It was suggested that cell vacuolation in bladder cancer tissues might be a morphological transformation of HPV infection and the latter might be involved in the carcinogenesis of bladder cancer.

关 键 词：膀胱肿瘤 HPV 肿瘤细胞空穴症 病因 

分 类 号：R737.140.2[医药卫生—肿瘤]