甲型肝炎病毒动物模型研究  

STUDIES IN COMMON MARMOSET AS A MODEL OF HEPATITIS A VIRUS.

作　　者：练幼辉[1] 曹逸云[1] 黄小琴[1] 罗其胜[1] 何继红[1] 高承刚 董德祥[1] 

机构地区：[1]中国医学科学院中国协和医科大学医学生物学研究所

出　　处：《现代预防医学》1997年第3期303-305,共3页Modern Preventive Medicine

基　　金：美国中华医学基金;国家"八.五"攻关课题

摘　　要：ＨＡＶ合—５２野毒株感染恒河猴和普通狨猴的结果表明，后者的易感性显然高于前者。用不同ＨＡＶ株实验性接种普通狨猴，结果显示均有特异性抗ＨＡＶ产生和粪便ＨＡＶ颗粒排出。接种Ｈ２株疫苗的狨猴无酶活性升高以及肝组织病理学改变，而接种不同野毒株者均有生化反应及肝脏病变。普通狨猴可成为ＨＡＶ研究的良好的动物模型。The results of rhesus monkeys and common marmosets infected with wild-type HAV He-52 showed that the latter was more susceptible to HAV. The responses of common marmoset to three different strains of HAV has been studied .Development of specific HAV antilodies in sera and exeretion of virus particles in stools were demonstrated in all animals .The animals inoculated with H2 strain vaccine showed no histopatological changes in liver tissues and on elevations of liver enzymae in activities.Nerertheless,there was appearance of lirer lesions and biachemical responese those received with wild-type HAV.Terefore ,the commom marmosets could be used as the experimental models for HAV research.

关 键 词：甲肝病毒 普通狨猴 肝组织病理 动物模型 

分 类 号：R512.610.2[医药卫生—内科学]