细胞周期素G_1、G_2在皮肤血管瘤组织中的表达及意义  

EXPRESSION AND SIGNIFICANCE OF CYCLINS G_1 AND G_2 IN HEMANGIOMA

作　　者：刘涓[1] 张端莲[2] 陕声国[3] 

机构地区：[1]武汉大学人民医院老年病科,430060 [2]武汉大学医学院组织胚胎教研室,430071 [3]武汉大学人民医院整形外科,武汉430060

出　　处：《中国组织化学与细胞化学杂志》2008年第1期14-19,共6页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金资助(30271345);湖北省科技厅资助(2003ABA164);湖北省卫生厅资助(JXIB075);湖北省科技厅资助(2004AA301c107)

摘　　要：目的探讨细胞周期素G1、G2与血管瘤发生发展及退化的关系。方法采用免疫组织化学S-P法对50例血管瘤和5例正常皮肤组织检测细胞周期素G1、G2的表达;对所获得的检测结果进行图像分析处理。结果增生期血管瘤内皮细胞胞浆或胞核内cyclin G1呈强阳性表达,退化期血管瘤内皮细胞胞浆内cyclin G1无表达;增生期血管瘤内皮细胞胞浆内无cyclin G2表达,退化期血管瘤内皮细胞胞浆内cyclin G2呈强阳性表达。增生期组与退化期组、正常皮肤组分别相比,细胞周期素G1阳性表达差异有显著性(P<0.05),退化期组与增生期组、正常皮肤组之间,细胞周期素G2的阳性表达差异有显著性(P<0.05)。结论细胞周期素G1、G2在血管瘤发生、发展及退化中起着重要作用。Objective To investigate the relationship between cyclins G1, G2 and hemangioma development. Methods The immunohistochemical and quantitative image analysis were used to detect cycline G1 and G2 expressions in 50 hemangioma and 5normal skin tissues. Results There were plenty of brown particles in proliferating hemangioma. , which showed strong cyclin G1 expression. There were few brown particles in involuting hemangioma which showed weak cyclin G1 expression. Few brown particles in proliferating hemangioma, showed weak cyclin G2 expression . While plenty of brown particles in involuting hemangioma, showed strong cyclin G2 expression. Cyclin G1 expression was significantly stronger in the proliferatimg phase and normal skin tissue respec （ P 〈 0. 05 ） ; And cyclin G2 expression as stronger in the than in the proliferative phase and in normal skin tissue respectively （P 〈 0. 05 ） . And cyclim G2 expression was stronger in the involuting phase than in the proliferating phase and normal tissue respectirely （P 〈 0. 05 ） . Conclusion The relationships between cyclins G1 or G2 and hemangionma development are different.

关 键 词：皮肤 血管瘤 细胞周期素G1 细胞周期素G2 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]