小剂量氢氯噻嗪对大鼠压力超负荷心肌肥厚的干预作用  

Effects of low dose hydrochlorothiazide on left ventricular hypertrophy induced by pressure-overload in rat

作　　者：吴小玲[1] 姜晨辉[1] 林少龙[1] 平静[1] 胡成花[1] 

机构地区：[1]南昌大学抚州医学分院,江西抚州344000

出　　处：《社区医学杂志》2008年第7期6-7,共2页Journal Of Community Medicine

摘　　要：目的本实验观察小剂量氢氯噻嗪对大鼠压力超负荷心肌肥厚的干预作用,为心肌肥厚的预防和治疗提供临床用药依据。方法采用腹主动脉结扎法制备压力超负荷型心肌肥厚大鼠模型,造模后第二天开始给药,氢氯噻嗪剂量分别为5mg/kg.d、10mg/kg.d,持续30天。以左室重量指数、心肌纤维直径等作为心肌肥厚的指标,观察药物的作用。结果结扎腹主动30天后,模型组与假手术组动物相比,心脏重量指数、心肌纤维直径显著增加(P<0.01)。氢氯噻嗪5mg/kg.d组、10mg/kg.d组的心脏重量指数明显低于模型组(P<0.01),且两组的心肌纤维直径均低于模型组(P<0.05)。结论小剂量氢氯噻嗪对大鼠压力超负荷心肌肥厚的具有干预作用。Objective This experiment observes the effects of low dose Hydrochlorothiazide （HCTZ） on left ventricular hypertrophy （LVH） induced by pressure - overload in rat, provides the clinical medication basis for the prevention and treatment ventricular hypertrophy. Methods The rat model with LVH was established by using the ligature of ventral aorta and then given drug for 30 days from 2nd day. The dosage of HCTZ is 5mg/kg·d, 10mg/kg·d. The rat left ventricular mass index （LVMI） ,the muscle fiber diameter （MFD） is taken as the indexes of myocardial hypertrophy. Results In the model group the LVMI and the MFD is increased compared with the sham- operated group （P 〈 0.01 ）. In HCTZ 5mg/kg·d group and 10mg/kg·d group the LVWI is lower than the model group obviously （ P 〈 0.01 ）, and the MDF is lower than the model group （ P 〈 0.05 ）. Conclusion HCTZ on LVH induced by pressure - overload in rat has the intervention function.

关 键 词：氢氯噻嗪 高血压病 心肌肥厚 

分 类 号：R983.1[医药卫生—药品]