^(90)钇玻璃微球肝内注射的放射分布研究  

Experiment Study of Radioactive Distribution of Intrahepatically Injected ^(90)Y Glass Microsphere

作　　者：李飞 杨浩[2] 卓忠雄[2] 

机构地区：[1]解放军第二五四医院超声室,300142 [2]重庆第三军医大学新桥医院超声科

出　　处：《中华超声影像学杂志》1997年第6期320-323,共4页Chinese Journal of Ultrasonography

摘　　要：在超声引导下将不同剂量^(90)Y玻璃微球(^(90)YGM)注入兔肝内,以观察局部注射后同位素的体内分布及注射区肝脏的组织学变化。结果表明,该方法同位素微球仅局限于注射区内。韧致辐射范围4.1～12.55 cm^2(平均8.45cm^2)。未发现肝外分流及非靶器官损伤。注射剂量35mci时,药物作用区肝细胞完全坏死。本研究表明该方法微球定位准确,可致局部高辐射能,因而可望成为非手术治疗肝癌的手段之一。Different doses of ^(90)Y glass microspheres weres injected into the livers of rabbits under ultrasound guidance to observe the distribution of isotope in the body and the histologic alteration in the liver. The result showed that the isotope microspheres were only limited at the injected areas. The areas o.f bremsstrahlung ranged 4.1～12.55cm^2(mean 8.45cm^2). Whole body scanning revealed that the isotope was not observed outside the liver and no injury of non-target organ was present. When the dose was 35 mci, complete necrosis appeared in the hepatic cells within the bremsstrahlung areas. The study indicales that intrahepatic injection of ^(90)Y glass microspheres is accurmuate in locallization, produces high local iradiation energy and may become a non-surgical way for treating carcinoma of liver.

关 键 词：同位素 韧致辐射 肝癌 钇90 玻璃微球 放射疗法 

分 类 号：R735.705[医药卫生—肿瘤]