内皮素在脑出血、脑梗死中的活性变化研究  

AN INVESTIGATION OF THE RELATIONSHIP BETWEEN ENDOTHELIN AND STROKE

作　　者：刘罡[1] 齐晓飞[1] 闫广泽 刘建军[1] 毛永军[1] 

机构地区：[1]内蒙古医学院第一附属医院

出　　处：《内蒙古医学院学报》1997年第3期34-36,共3页Acta Academiae Medicinae Neimongol

摘　　要：采用放射性免疫法，对脑血管病急性期与恢复期血浆内皮素浓度进行观察，并与健康同龄人对照。结果显示脑出血与梗死的急性期血浆内皮素明显升高（Ｐ＜００１）。２０天后渐恢复正常。内皮素浓度与出血部位、量及梗死的大小和多少有关，与年龄、性别无关。认为脑梗死患者及早应用钙通道阻滞有益，并可根据内皮素的浓度判断疾病的恢复及预后。Endothelin in the stroke patients was assessed respectively in acute and recovery phase by using radioimmunity measures. The results showed that the level of plasma endothelin in stroke patients was increased significantly in acute phase compared with normal control, and restored gradually 20 days later. The endothelin was related to the site and amount of the hemorrhage and the focus number and size of the infarction. There was no relation between endothelin concentration and age or sex. The author holds that it is useful to administer calciumchannel blockers as early as possible, and that the prognosis can be determined according to the endothelin concentration.

关 键 词：内皮素 脑出血 脑梗死 放射免疫法 

分 类 号：R743.3[医药卫生—神经病学与精神病学]