吡啶-3-甲醛缩氨基硫脲合镍(Ⅱ)、锌(Ⅱ)配合物的合成、晶体结构及生物活性(英文)  

Synthesis, Crystal Structures, and Bioactivities of Ni~Ⅱ and Zn~Ⅱ Complexes with Pyridine-3-carbaldehyde Thiosemicarbazone

作　　者：边贺东[1] 李春英[1] 梁宇宁[1] 郭桂全[1] 于青[1] 梁宏[1] 

机构地区：[1]广西师范大学化学化工学院,桂林541004

出　　处：《无机化学学报》2008年第4期527-533,共7页Chinese Journal of Inorganic Chemistry

基　　金：教育部高校青年教师奖资助项目;广西师范大学博士启动基金

摘　　要：本文合成并表征了吡啶-3-甲醛缩氨基硫脲(HL)合镍(Ⅱ)、锌(Ⅱ)配合物。在配合物[NiL2](1)中,镍(Ⅱ)离子与来自2个脱氢配体的2个氮原子和2个硫原子配位,形成四配位的平面正方形构型。在配合物[Zn(HL)2(C2H5OH)2(H2O)2](NO3)2(2)中,锌(Ⅱ)离子与2个中性配体、2个乙醇分子和2个水分子配位,配位原子在锌(Ⅱ)离子周围形成畸变的八面体构型。通过荧光吸收法研究了配合物1、2与小牛胸腺DNA的作用机理。结果表明,这2个配合物均以插入形式进入DNA的碱基对。此外,还研究了配体及2个配合物对金黄色葡萄球菌、乙型溶血性链球菌、肺炎链球菌、炭疽杆菌的抗菌活性。结果表明,配体及配合物1对上述测试菌种无抑制作用,配合物2对前面3种有弱的抑菌作用。The NiⅡ and ZnⅡ complexes with pyridine-3-carbaldehyde thiosemicarbazone （HL） have been synthesized and characterized by X-ray diffraction. In the [NiL2] （1）, the NiⅡ atom was four-coordinated to form a square geometry by two nitrogen atoms and two sulfur atoms from two different deprotonated ligands. In [Zn （HL）2（C2H5OH）2（H2O）2] （NO3）2 （2）, the ZnⅡ atom was in a distorted octahedral geometry coordinated by two neutral ligands, two ethanol molecules, and two water molecules. The binding of the two complexes with calf thymus DNA has been investigated by absorption, luminescence titrations. The results suggest that both the two complex intercalates into DNA base pairs. Antimicrobial activities of the free ligand and the two complexes against Staphylococcus Aureus, β-hemolytic streptococcus, Streptococcus Prteumoniae, Bacillus Anthracis shows that the free ligand and 1 did not inhibit the growth of the test microorganisms and 2 showed weak activities against the three former tested microorganisms.

关 键 词：镍Ⅱ配合物 锌Ⅱ配合物 氨基硫脲 DNA作用 抗菌活性 

分 类 号：O614.813[理学—无机化学] O614.241[理学—化学]