血清HGF水平与肝癌临床病理关系分析  

RELATIONSHIP BETWEEN LEVELS OF HGF AND THE CLINIC PATHOLOGIC CHARACTERS OF HEPATOCELLULAR CARCINOMA

作　　者：许伦兵[1] 耿小平[1] 钱叶本[1] 

机构地区：[1]安徽医科大学第一附属医院,合肥230022

出　　处：《肝胆外科杂志》2008年第2期137-140,共4页Journal of Hepatobiliary Surgery

摘　　要：目的检测肝癌患者术前血清HGF水平,分析血清HGF水平与肝癌临床病理特征的关系。方法选择2001年1月至2002年12月我院肝脏外科行手术治疗的原发性肝癌病例共47例,采用ELISA法检测患者术前外周血中的HGF水平,先比较肝癌组、肝硬化组、正常对照组之间的血清HGF水平,再对所有肝癌病例按临床病理特征进一步分组,比较HGF水平在不同组别间有无差异。结果肝癌患者的血清HGF水平显著高于正常对照组,肝癌合并肝硬化组的血清HGF水平显著高于肝癌未合并肝硬化组。结论肝癌患者血清HGF水平升高可能与合并肝硬化有关;血清HGF水平与肝癌临床病理特征无关,HGF可能促进肝细胞癌的发生。Objective To investigate the relationship between the levels of HGF and the clinic pathologic characters in patients with hepatocellular carcinoma. Methods From January 2001 to December 2002, 47 patients with hepatocellular carcinomas were hospitalized in the department of Hepatobiliary Surgery, First Affiliated Hospital of Anhui Medical University. Enzyme linked immunosorbent assay method was used to detect the level of HGF in serum; and the level of HGF in the group of normal control,hepatocellular carcinoma and cirrhosis. Patients with hepatocellular carcinoma were divided into several groups according to clinic pathologic characters to compare the statistical difference. Results The HGF levels in patients with hepartocellular carcinoma were higher than those in normal control（P 〈 0.05）. In the group of hepatocellular carcinoma, the levels of HGF in serum was higher in patients with cirrhosis than those in patients without cirrhosis （0. 60 ± 0. 21 ng/ml vs 0. 42 ± 0. 17 ng/ml, P 〈 0.01 ）. Conclusion The levels of HGF is related to cirrhosis. There were no relationships between the levels of HGF and the clinic pathologic characters in patients with hepatocellular carcinoma. HGF may promote the tumor development.

关 键 词：肝细胞癌 肝细胞生长因子 

分 类 号：R735.7[医药卫生—肿瘤]