CD26、Ki67和表皮生长因子受体在甲状腺肿瘤中的表达及其诊断意义  

Expressions of CD26, Ki67 and EGFR proteins in primany thyroid neoplasms and their value in differential diagnosis

作　　者：尚立芝[1] 杨宇明[1] 李德祥[1] 韦大文[2] 程晓菊[1] 

机构地区：[1]遵义医学院病理学教研室,563003 [2]河南中医学院基础医学院

出　　处：《中华内分泌代谢杂志》2008年第2期174-177,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：贵州省科委资助项目（983055）

摘　　要：目的观察CD26、Ki67和表皮生长因子受体（EGFR）在甲状腺良恶性肿瘤中的表达，探讨其鉴别诊断意义，并寻找分化型甲状腺癌标志物。方法用免疫组化S-P法检测分化型甲状腺癌、腺瘤各50例中CD26、Ki67和EGFR蛋白的表达，并分析它们的相关性。结果CD26、Ki67和EGFR的阳性表达率、表达强度在腺癌组显著高于腺瘤组、尤其滤泡性腺癌显著高于滤泡性腺瘤组。结论CD26、Ki67和EGFR的异常表达尤其CD26可能对滤泡上皮起源的甲状腺癌与腺瘤的鉴别诊断、预后判断有参考意义。Objective To observe the expressions of CD26, Ki67 and epidermal growth factor receptor （EGFR） proteins in thyroid neoplasms, to explore their value in differential diagnosis between benign and malignant thyroid neoplasms and to search for molecular marker in well-differentiated thyroid carcinomas. Methods The expressions of CD26, Ki67and EGFR proteins were examined by immunohistochemistry in 50 differentiated thyroid carcinomas （ TC ） and 50 thyroid adenomas （ TA ） and their relationships were analyzed. Results The positive rate and expression intensity of CD26 ,Ki67and EGFR proteins in TC were significantly higher than those in TA, and especially higher in follicular TC than those in follicular TA. Conclusion The abnormal expressions of CD26, Ki67and EGFR proteins appear to be valuable in differential diagnosis and predicting prognosis of thyroid carcinomas, especially CD26 can be used as a diagnostic marker in well-differentiated carcinoma of follicular cell origin.

关 键 词：抗原 CD26 KI-67抗原 受体 表皮生长因子 甲状腺肿瘤 诊断 鉴别 

分 类 号：R736.1[医药卫生—肿瘤]