糖尿病合并无症状脑梗死的危险因素及实验室检查结果分析  

Risk Factors and Laboratory Examinations Results of Silent Brain Infarction in 50 Patients with T2DM

作　　者：龚敏[1] 王爱华[1] 曾艺鹏[1] 

机构地区：[1]上海市南汇区中心医院内分泌科,201300

出　　处：《中国全科医学》2008年第10期859-860,871,共3页Chinese General Practice

摘　　要：目的探讨糖尿病合并无症状脑梗死(SBI)的危险因素,分析实验室检查结果。方法通过分析50例糖尿病合并SBI患者的临床资料,然后与50例非SBI的糖尿病患者进行危险因素比较,并分析两组患者的实验室和彩超检查结果。结果两组患者高血压、冠心病、心电图异常和眼底动脉硬化的发生率及糖尿病、高血压、冠心病病史间差别有统计学意义(P<0·05);空腹血糖值和空腹血糖>8·3mmol/L、血脂异常、血液流变学异常、血细胞比容增高及血尿素氮(BUN)/肌酐(Cr)增高的发生率间差别亦有统计学意义(P<0·05);颈动脉内膜中层厚度及颈总动脉(CCA)和颈内动脉(ICA)起始处的管壁内径、舒张末期流速、平均流速和阻力指数间差别亦有统计学意义(P<0·05)。结论糖尿病患者由于血糖和血脂的代谢紊乱,易发生SBI。故规律生活、合理饮食,严格控制血压、血糖,减少肥胖,改善脑缺血及脑代谢才能预防糖尿病SBI的发生。Objective To analyze the risk factors and analysis the laboratory examinations rusults of silent brain infarction （SBI） in 50 patients with T2DM. Methods We analyzed the clinical data of 50 patients with T2DM combined with SBI and 50 without SBI, and then compared the results of laboratory and color ultrasound. Results There was significant difference in the incidence of hypertension, coronary artery disease （CAD）, electrocardiographic abnormality and angiosclerosis of eye fundus, and the history of diabetes, hypertension and CAD between the groups （ P 〈 0. 05 ） ; significant difference was found in fasting blood sugar, fasting blood sugar 〉 8. 3 mmol/L, abnormal blood fat and abnormal hemorheology, and in the incidence rates of the increase of red cell pack and blood urea nitrogen （BUN） /creatinine （CR） between the two groups （ P 〈 0.05） significant difference was also noted in the thickness of carotid artery intima, the inner diameter of vessel wall of CCA and ICA, D, MN and IR between two groups （ P 〈 0. 05）. Conclusion Regular life, reasonable food and drink, strict control of blood pressure and blood sugar, good improvement of cerebral ischemia and cerebral metabolism could prevent the genesis of T2DM complicated with （SBI）.

关 键 词：糖尿病 无症状脑梗死 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]