大肠癌抑癌基因蛋白P33^(ING1)表达的临床意义  

Study on the Expression of P33^(ING1) in Colorectal Carcinoma

作　　者：李春光[1] 熊斌[1] 蓝海[1] 

机构地区：[1]武汉大学中南医院肿瘤科,湖北武汉430071

出　　处：《医学新知》2008年第2期102-103,共2页New Medicine

摘　　要：目的研究抑癌基因蛋白P33ING1在大肠癌组织中的表达及其与肿瘤生物学行为的相关性。方法对54例大肠癌手术切除的癌组织和癌周正常组织,应用免疫组织化学方法检测抑癌基因蛋白P33ING1的表达,探讨它与肿瘤生物学行为的相关性。结果P33ING1在正常组织中呈高表达,在肿瘤组织中呈低表达;并与组织类型、淋巴结转移、临床分期和5年生存率相关(P<0.05)。结论抑癌基因蛋白P33ING1在大肠癌中表达水平降低,可能是癌肿发生、生长和浸润转移的重要因素,可作为判断肿瘤恶性程度的重要指标。Objective To investigate the expression of P33ING1 in colorectal carcinoma and the relationship between this protein and the biological behavior of carcinoma. Methods lmmunohistochemical method was used to detect the expression of P33ING1 in the carcinoma tissues and normal tissues around the foci. The relationship between the protein and the biological activity of carcinoma was further investigated. Results The expression of P33ING1 was low in carcinoma tissues but high in normal tissues. The expression of the protein was related to the tissue type, metastasis of lymph node, Dukes stage, and five-year survival rate. Conelussion The low expression of P33ING1 in carcinoma may be important factors involved in carcinogenosis, development, invasion and metastasis, which can be used as predictors of malignant behavior of colorectal carcinoma.

关 键 词：大肠癌 抑癌基因INGI 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]