Glut-1、COX-2在子宫内膜腺癌及其癌前病变中的表达  

Expressions of Glut-1 and COX-2 in Endometrial Adenocarcinoma and Precancerous Lesion

作　　者：朱正鹏[1] 贾国凤[1] 杨微荣[1] 沈勤[1] 马健波[1] 李凯[1] 谢永辉[1] 

机构地区：[1]郧阳医学院附属东风医院病理科,湖北十堰442008

出　　处：《肿瘤防治研究》2008年第4期266-268,共3页Cancer Research on Prevention and Treatment

基　　金：湖北省教育厅重点科学技术研究项目(B200524004);湖北省十堰市科技局科技攻关项目(2005ZD048)

摘　　要：目的研究Glut-1、COX-2在子宫内膜腺癌及其癌前病变中的表达特点及其诊断价值。方法应用免疫组织化学SP法检测了20例正常增生期子宫内膜、23例单纯性子宫内膜增生、21例复杂性子宫内膜增生、43例非典型性子宫内膜增生、25例子宫内膜腺癌中Glut-1、COX-2的表达。结果Glut-1和COX-2在各实验组中的阳性表达率增生期子宫内膜组为0和10.0%,单纯性增生组为0和9.1%,复杂性增生组为4.8%和14.3%,低级别非典型增生组为20.0%和25.0%,高级别非典型增生组为52.2%和52.4%,腺癌组为88.0%和91.7%;Glut-1、COX-2在各实验组间差异均有统计学意义(P均=0.000),在高级别非典型增生组与子宫内膜腺癌组间差异均有统计学意义(P<0.01)。COX-2与Glut-1在各组的表达呈显著正相关关系(P<0.01)。结论Glut-1、COX-2可能在子宫内膜癌的发生发展中共同发挥重要作用,两者联合检测对子宫内膜腺癌及癌前病变的鉴别诊断有较高的诊断价值。Objective To study immunohistochemical expression of Glut-1 and COX-2 in endometrial adenocarcinoma and precancerous lesion. Methods Immunohistochemical staining S-P method was used to detect the expression of Glut-1 and COX-2 in 20 cases of normal proliferative endometrium, 23 cases of simple endometrial hyperplasia, 21 cases of complex endometrial hyperplasia, 43 cases of atypical endometrial hyperplasia, 25 cases of endometrial adenocarcinoma. Results The positive expression rates of Glut-1 and COX-2 were 0% and 10. 0% in normal proliferative endometrium, 0% and 9. 1% in simple endometrial hyperplasia, 4.8% and 14. 3% in complex endometrial hyperplasia, 20. 0% and 25. 0% in low-grade atypical endometrial hyperplasia, 52. 2% and 52. 4% in high-grade atypical endometrial hyperplasia, 88. 0% and 91.7% in endometrial adenocarcinoma. There were all significant difference between benign, hyperplastic and malignant endometrial epithelia, the difference between endometrial adenocarcinoma and high-grade atypical endometrial hyperplasia were also statistically significant. Positive correlation was also found between COX-2 and Glut-1 expression（P = 0. 000）. Conclusion Abnormal expression of Glut-1 and COX-2 may contribute to the pathogenesis and development of the endometrical carcinoma, the combined use of Glut-1 and COX-2 is valuable in distinguishing endometrial adenocarcinoma from endometrial hyperplastic lesions.

关 键 词：子宫内膜腺癌 GLUT-1 COX-2 

分 类 号：R737.33[医药卫生—肿瘤]