CD56(+)的弥漫性大B细胞性淋巴瘤临床病理观察  

CD56-positive diffuse large B cell lymphoma:a clinicopathological observation

作　　者：黄文斌[1] 赵建华[1] 王劲松[1] 黄悦[1] 李俐[1] 杨小兵[1] 蒋春莲[1] 

机构地区：[1]南京医科大学附属南京第一医院病理科,南京210006

出　　处：《诊断病理学杂志》2008年第2期121-123,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨CD56(+)的弥漫性大B细胞性淋巴瘤(DLBCL)的临床病理学特征、免疫表型和鉴别诊断。方法对1例CD56(+)的DLBCL进行HE和免疫组化染色,并进行文献复习。结果组织学上,肿瘤细胞中等大小到较大,弥漫排列,核轮廓不规则,染色质细腻,分布较均匀,可见小核仁,核分裂象多见。免疫组化肿瘤细胞CD20、CD79a、Pax-5、CD10和CD56(+),而CD3、CD45RO、CKpan、EMA、HMB45、粒酶B和穿孔素均为(-)。结论CD56(+)的DLBCL可能代表着DLBCL的一种新的和少见的亚型。Objective To study the clinical pathological features, immunophenotype and differential diagnosis of CD56-positive diffuse large B cell lymphoma （DLBCL）. Methods One case of CD56^＋ DLBL was stained by HE and immunohistochemical technique. Results Microscopically, tumor ceils were medium to large in size which awaked in diffusely, and nuclear contour was irregularity with variably fine chromatin and conspicuous small nucleoli. Mitosis was commonly seen. Immunohistochemically, tumor cells were positive for CD20, CD79a, Pax-5, CD10 and CD56, but negative for CD3, C3M5RO, CKpan, EMA, gramB and perforin. Conclusion CD56-positive large B cell lymphoma may represent a new and unusual subset of DLBCL.

关 键 词：淋巴瘤 B细胞 CD56 鉴别诊断 

分 类 号：R733.1[医药卫生—肿瘤]