纳洛酮治疗肝性脑病疗效观察  

Observation on effects of naloxone on patients with hepatic encephalopathy

作　　者：苏玉严[1] 

机构地区：[1]海南省农垦总局医院,海南海口570311

出　　处：《中国热带医学》2008年第5期805-806,共2页China Tropical Medicine

摘　　要：目的探讨纳络酮注射液治疗肝性脑病的临床疗效。方法将80例肝性脑病患者随机分为两组,对照组38例给予综合抗肝昏迷处理,治疗组42例在综合抗肝昏迷处理的基础上加用纳络酮。结果治疗组总有效率95.2%,对照组为81.5%,差异有统计学意义(P<0.05)。治疗后肝昏迷计分值分别为1.17±0.34、0.70±0.22,差异有显著性(P<0.01)。结论纳络酮是治疗肝性脑病的安全、有效药物,值得临床推广。Objectlve To observe the therapeutic effects of naloxone hydrechlofide for injection on patients with hepatic encephalopathy（HE）. Methods Eighty cases of HE were randomly divided into the treatment group consisted of 42 cases treated with naloxone and a complex treatment and the control group consisted of 38 cases only received a complex treatment. Results The total effective rate of the treatment group was 95.2% and that of control group was 81.5% , showing significant difference （ P 〈 0.05 ）. The HE scores of treatment of cases in the treatment group after treatment was 0.70±0.22 lower than that of the control group （ 1.17± 0.34） , also showing significant difference （P 〈 0.01 ）. Conclusion Naloxone hydrochlofide for injection is safe and effective fpr treatment of HE.

关 键 词：纳络酮 肝性脑病 疗效 

分 类 号：R747.9[医药卫生—神经病学与精神病学]