血管瘤样纤维组织细胞瘤1例报告并文献复习  

Angiomatoid Fibrous Histiocytoma:A Case Report and Review of Literature

作　　者：梁晋军[1] 付文荣[1] 王桂英[1] 王新国[1] 盛均逸[1] 孙凯[1] 

机构地区：[1]华中科技大学同济医学院附属襄樊医院病理科,湖北襄樊441021

出　　处：《中国误诊学杂志》2008年第15期3540-3541,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨血管瘤样纤维组织细胞瘤临床病理特点及诊断、鉴别诊断要点。方法:收集1例血管瘤样纤维组织细胞瘤的临床资料,光镜和免疫组化观察并复习文献。结果:血管瘤样纤维组织细胞瘤好发于儿童和青少年四肢,其组织学特点为:(1)假血管瘤样出血性囊腔;(2)瘤细胞似纤维母细胞和组织样细胞;(3)瘤周形成假包膜及淋巴细胞为主的慢性炎细胞浸润。免疫组化组织细胞标记CD 68阳性,肌源性标记DES、SM A,神经标记S-100,血管标记CD 34均为阴性支持组织细胞起源。结论:血管瘤样纤维组织细胞瘤是一种罕见的、具有独特临床特征、组织学特点及预后的中间型低度恶性软组织肿瘤,提高对其形态学的认识、结合临床特征及免疫组化可提高诊断准确率。Objective： To investigate the clinicopathologic characteristics,diagnostic and differential diagnosis criteria of angiomatoid fibrous histiocytoma （AFH）. Methods：A case of AFH was studied by clinic data,microscope and immunohistochemistry as well as literature review. Results： AFH occurring chiefly in children and young adults on the extremitities, there were three characteristic microscopic findings：（1）pseudoangioma-like hemorrhagic cyst. （2） fibroblast and histiocytic-like tumor cells. （3） tumor surrounding pseudocapsule with distinct chronic inflammatory cell infiltrate. Immunohistochemistry confirmed that AFH was fibrohistiocytic origin. Conclusions： AFH is a rare intermediate low malignant soft tissue tumor. It has particular clinicalpathologic characteristics and a relatively good prognosis. Enhance the recognition of angiomatoid fibrous histiocytoma,combining clinic and immunohistochemical characters can increase diagnosis accuracy.

关 键 词：皮肤肿瘤 组织细胞瘤 纤维 人类 病例报告[文献类型] 

分 类 号：R739.5[医药卫生—肿瘤] R730.262[医药卫生—临床医学]