Notch1在大肠癌中的表达及临床意义  

Expression of Notchl protein and its clinicopathological significance in colorectal carcinomas

作　　者：卢光新[1,2] 宋军[2] 徐少勇[2] 王斌[2] 陈珺[2] 杨桂芳[1] 

机构地区：[1]武汉大学中南医院病理科,湖北武汉430070 [2]郧阳医学院附属人民医院消化内科

出　　处：《中国医师杂志》2008年第4期469-471,共3页Journal of Chinese Physician

基　　金：湖北省教育厅科研重大项目基金资助项目（200524001）

摘　　要：目的研究大肠癌中Noteh1蛋白的表达以及Noteh1蛋白与大肠癌的临床病理关系。方法对30例大肠癌标本组织及18例正常大肠黏膜组织用免疫组织化学S—P方法检测其Noteh1蛋白的表达情况。结果Noteh1蛋白在大肠癌中高表达，其平均阳性率为（45．5±0．7）％，Noteh1蛋白在正常大肠黏膜中低表达，其平均阳性率为（6．8±0．9）％，两者差异有统计学意义（P〈0.05）。Noteh1蛋白在不同年龄，性别，肿瘤部位、有无淋巴结转移及Dukes分期中的表达差异无统计学意义（P〉0．05），但Noteh1蛋白在不同分化程度的大肠癌中的表达差异有统计学意义（P〈0．05）。结论Noteh1蛋白与大肠癌的发生有关，是潜在的致癌基因。Noteh1有望成为大肠癌治疗新的靶基因。Objective To investigate the expression of Notchl protein and its elinieopathologieal characteristics in eoloreetal carcinomas. Methods The expression and location of Notchl protein were determined using immunohistochemical S-P method in 30 colorectal carcinomas and 18 normal colorectal tissues. Results The average positive rate of Notchl protein was 45.5 ± 0. 7% in colorectal carcinomas and 6. 8 ±0. 9% in normal colorectal tissues. There was significant difference between colorectal carcinomas and normal colorectal tissues （ P 〈0. 05）. The expression of Notchl protein in different age, sex, tumor site, nodal involvement and Dukes stage had no significant difference. The expression of Notchl protein in different histology grade had significantly statistical difference. Conclusion Notchl expression was associated with the development of colorectal carcinoma. Notchl was the potential oncogenic gene. Nothcl would become the new target of the colorectal tumor therapy in the future.

关 键 词：肠肿瘤 基因 大肠黏膜组织 癌标本组织 

分 类 号：R735.34[医药卫生—肿瘤]