脂溢性角化病皮损中Smad4 mRNA表达水平的变化  

Comparison of expression level of Smad4 mRNA in seborrheic keratosis and normal control skin

作　　者：杨扬[1] 何威[1] 吴军[1] 何云志[1] 黄海[1] 林自华[1] 马宏民[1] 

机构地区：[1]第三军医大学新桥医院皮肤科,重庆400037

出　　处：《重庆医学》2008年第8期833-834,836,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(30371298)

摘　　要：目的探讨转化生长因子β(TGF-β)/Smad信号转导途径中共有Smad——Samd4 mRNA在脂溢性角化病皮损中的表达水平及其意义。方法应用反转录-实时定量聚合酶链反应(RT and quantitative Real-Time PCR)方法分别检测脂溢性角化病皮损与正常对照皮肤中Smad4的mRNA表达情况。结果脂溢性角化病皮损中Smad4的mRNA表达水平显著低于正常对照皮肤。结论脂溢性角化病皮损中Smad4表达下调可能干扰TGF-β信号下传,使TGF-β抑制上皮过度增生的作用不能有效发挥,从而促进了脂溢性角化病皮损中表皮的过度增生。Objective To investigate the expression and significance of Common-partner Smad -Smad4 mRNA in seborrheic keratosis. Methods The RT quantitative real-time PCR was used to detect the expression level of Smad4 mRNA in specimens of seborrheic keratosis and normal control skin respectively. Results The expression level of Smad4 mRNA was significantly down-regulated in seborrheic keratosis in comparison with those in normal control skin. Conclusion Down-regulation of Smad4 might interfere with TGF-β signaling transduction pathway and contribute to the excessive hyperplasia of epidermis in seborrheic keratosis.

关 键 词：脂溢性角化病 转化生长因子Β SMAD4 信号转导 

分 类 号：R739.5[医药卫生—肿瘤]