茎突后间隙侵犯与淋巴结N2期鼻咽癌预后的关系  

Relationship of post-styloid space involvement with prognosis of patients with nasopharyngeal carcinoma in N2 stage

作　　者：彭苗[1] 谢方云[1] 胡伟汉[1] 邹国荣[1] 李济时[1] 

机构地区：[1]中山大学肿瘤防治中心华南肿瘤学国家重点实验室放疗科,广东广州510060

出　　处：《解剖学研究》2008年第2期136-140,共5页Anatomy Research

基　　金：广东省科技计划项目(2006B36001009)

摘　　要：目的探讨茎突后间隙侵犯对无远处转移且淋巴结分期为N2鼻咽癌患者预后的影响。方法收集149例淋巴结分期N2期初治鼻咽癌住院患者资料进行分析,均行CT扫描,采用单因素及多因素结合的方法分析茎突后间隙侵犯对其预后的影响。结果149例患者中,茎突后间隙无受侵的56例,茎突后间隙受侵的93例。单因素分析结果显示,茎突后间隙无侵犯、有侵犯的5年总生存率和5年无远处转移生存率分别为78.7%、49.7%(P=0.002)和86.4%、66.0%(P=0.014)。多因素分析结果显示,茎突后间隙侵犯为总生存率、无远处转移生存率的独立预后因素(P<0.05)。5年的总生存率为61.1%,5年局部区域无复发生存率为82.2%,5年无远处转移生存率为74.2%。结论茎突后间隙侵犯为淋巴结分期N2期鼻咽癌患者不利预后因素。Objective To assess the prognosis influence of post-styloid space involvement of the patients with nasopharyngeal carcinoma （NPC） in the stage T1-4N2M0 （UICC2002 6th staging system）. Methods 149 patients with NPC in N2 stage first treated in Sun Yat-sen university cancer center were analyzed. All the patients were examined by CT scan before treated. Potentially significant parameters were analyzed by both univariate analysis and multivariate analysis methods. Results There were 56 patients without post-styloid space involvement and 93 patients with post-styloid space involvement. In univariate analysis, the 5-year OS and DMF of patients with NPC in N2 stage without post-styloid space involvement and with it were 78.7% ,49.7%（P=0.002）and 86.4% ,66.0%（P=0.014）. In multivariate analysis, post-styloid space involvement was an independent adverse prognosis factor of OS and DMF （P〈0.05）. The 5-year overall survival rate （OS） was 61.1%. The 5-year local-regional free rate （LRF） was 82.2%. The 5-year distant metastasis free survival rate （DMF） was 74.2%. Conclusion In the N2 stage subgroup of NPC, the patients with post-styloid involvement have poorer prognosis.

关 键 词：鼻咽癌/放射疗法 颈淋巴结 茎突后间隙 预后 

分 类 号：R739.63[医药卫生—肿瘤] R735.2[医药卫生—临床医学]