多原发大肠癌70例临床分析  

Clinical Analyses of 70 Cases of Multiple Primary Colorectal Carcinoma

作　　者：王玮[1] 周志伟[1] 万德森[1] 卢震海[1] 陈功[1] 潘志忠[1] 李力人[1] 伍小军[1] 丁培荣[1] 

机构地区：[1]华南肿瘤学国家重点实验室

出　　处：《癌症》2008年第5期505-509,共5页Chinese Journal of Cancer

摘　　要：背景与目的:多原发大肠癌在大肠癌中并非少见,但其生物学行为较独特。本研究探讨多原发大肠癌(MPCC)的临床特点、诊断、外科治疗及预后。方法:对1997～2003年间手术治疗的70例MPCC患者的临床资料进行回顾性研究,其中同时性多原发大肠癌(SC)61例,异时性多原发大肠癌(MC)9例,并结合随访资料进行生存分析。结果:55例患者术前经肠镜、钡灌肠或CT诊断,15例患者因远端肿瘤过大无法进镜于术中诊断。70例患者中伴发结肠多发腺瘤性息肉者33例。除3例患者肿瘤广泛播散仅行短路手术外,其余均同期手术切除。其中根治性切除52例,姑息性切除15例。总的3年和5年生存率分别为65.7%和45.7%,其中根治性切除患者的3年和5年生存率分别为78.1%和59.3%。结论:MPCC的发生过程与腺瘤及息肉关系密切。其手术治疗并无固定模式,需根据肿瘤的位置、范围、间距以及患者的综合情况等决定。MPCC总体预后较好。应着重随访伴发腺瘤及息肉的MPCC患者。BACKGROUND ＆ OBJECTIVE. Multiple primary colorectal carcinoma （MPCC） is not rarely seen, but it possesses a unique biological characters. This study was to investigate the clinical characteristics, diagnosis, therapeutic principle and prognosis of MPCC. METHODS： Data of 70 MPCC patients, treated by operation from 1997 to 2003, were analyzed. Of the 70 patients, 61 had synchronous carcinoma （SC） and 9 had metachronous carcinoma （MC）. RESULTS： Fifty-five patients were diagnosed by colonoscopy, barium enema or CT scan pre-operationally, while 15 were diagnosed intra-operationally due to the oversized tumor at the distal end of the colon. Thirty-three patients had colorectal carcinoma accompanying with adenoma and multiple polyps. All the patients underwent surgical resection except 3, who received short-circuit operation because of unresectable lesions. Fifty-two patients received radical resection, while 15 received palliative resection due to hepatic or peritoneal metastasis. The overall 3- and 5-year survival rates were 65.7% and 45.7%. In the patients who received radical resection, the 3- and 5-year survival rates were 78.1% and 59.3%. CONCLUSIONS： The occurrence of MPCC is largely related with adenomas and polyps. The extent of resection should be individually determined by the lesion location, range, the distance of lesions as well as the general condition of the patients. Prognosis of MPCC is relatively good. The patients accompanying with adenoma and multiple polyps should be followed up intensively.

关 键 词：结直肠肿瘤 多原发癌 腺瘤 外科治疗 预后 

分 类 号：R735.34[医药卫生—肿瘤]